| Myocardial perfusion and coronary flow reserve assessed by positron emission tomography in patients after Fontan-like operations. | |
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MedLine Citation:
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PMID: 12545320 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ventricular dysfunction in patients after Fontan-like operations (FLOs) is a serious complication that might contribute to poor long-term results. Ischemic heart disease will have debilitating consequences on a Fontan heart. Ten patients (15.8 +/- 5.01 years) after FLO had transesophageal echocardiography and cardiac catheterization 9.3 +/- 4.2 years after surgery. Myocardial perfusion was assessed by NH3-positron emission tomography (rest/adenosine) and compared with that of 10 healthy adults (26.1 +/- 6.3 years). Ventricular function was normal in 4 and reduced in 6 patients; end systolic and end diastolic meridional wall stress was significantly elevated in the FLO group. Coronary angiography revealed no stenosis of the coronaries. Compared to normals, myocardial blood flow (MBF) at rest was higher in the FLO group (0.99 +/- 0.25 vs 0.77 +/- 0.17 ml/g/min, p <0.05), whereas MBF after vasodilatation (2.12 +/- 0.78 vs 3.10 +/- 0.85 ml/g/min, p <0.05) and coronary flow reserve (CFR) was reduced (2.5 +/- 0.88 vs 4.1 +/- 1.01, p <0.05), especially in those with impaired ventricular function. Coronary vascular resistance after vasodilatation was elevated in the FLO group (38.2 +/- 17.4 vs 24.5 +/- 8.3 mmHg/ml/g/min, p <0.05). Altered MBF, increased meridional wall stress, and impaired CFR are common findings in FLO. Attenuated CFR and reduced ventricular function are significantly correlated and may be risk factors for the long-term outcome. |
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Authors:
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M Hauser; F M Bengel; A Kühn; U Sauer; S G Nekolla; A Eicken; M Schwaiger; J Hess |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2003-01-28 |
Journal Detail:
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Title: Pediatric cardiology Volume: 24 ISSN: 0172-0643 ISO Abbreviation: Pediatr Cardiol Publication Date: 2003 Jul-Aug |
Date Detail:
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Created Date: 2003-07-04 Completed Date: 2003-11-20 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 8003849 Medline TA: Pediatr Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 386-92 Citation Subset: IM |
Affiliation:
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Deutsches Herzzentrum München, Pediatric Cardiology, Lazarettstrasse 36, 80636 Munich, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Blood Flow Velocity Case-Control Studies Child Cohort Studies Coronary Angiography Coronary Circulation / physiology Echocardiography, Transesophageal Electrocardiography Female Follow-Up Studies Fontan Procedure / adverse effects, methods* Heart Catheterization Heart Function Tests Hemodynamics / physiology Humans Male Myocardial Ischemia / etiology, radionuclide imaging* Probability Reference Values Risk Assessment Sensitivity and Specificity Severity of Illness Index Statistics, Nonparametric Tomography, Emission-Computed* Tricuspid Atresia / surgery Ventricular Dysfunction, Left / physiopathology, radionuclide imaging* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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