Document Detail

Myocardial perfusion assessed by contrast echocardiography correlates with angiographic perfusion parameters in patients with a first acute myocardial infarction successfully treated with angioplasty.
MedLine Citation:
PMID:  18685744     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Angiographic flow in an epicardial artery does not define perfusion at the microvascular level.
AIM: To compare myocardial contrast echocardiography (MCE) with angiographic methods of assessing microvascular reperfusion in patients with acute myocardial infarction (AMI).
METHODS: One hundred consecutive patients with a first ST segment elevation myocardial infarction and single-vessel disease were successfully treated with primary percutaneous coronary intervention. Regional contrast score index (RCSI), corrected Thrombolysis In Myocardial Infarction (TIMI) frame count (cTFC), TIMI myocardial perfusion grade (TMPG) and myocardial blush grade were evaluated.
RESULTS: Among 717 asynergic segments on MCE, 168 revealed a lack of perfusion. TMPG and cTFC correlated significantly with RCSI (P=0.031 and P=0.027, respectively). Myocardial blush grade did not correlate with RCSI (P=0.067). Patients with anterior AMI had significantly more segments with a perfusion defect on MCE than patients with inferior AMI (P=0.0001).
CONCLUSIONS: MCE results correlate with angiographic methods of perfusion assessment such as TMPG and cTFC. Anterior AMI is associated with a greater extent of perfusion defect. MCE results correlate also with recovery of systolic left ventricular function and clinical outcome at six month follow-up.
Anna Tomaszuk-Kazberuk; Bozena Sobkowicz; Karol Kaminski; Kamil Gugala; Grzegorz Mezynski; Slawomir Dobrzycki; Anna Lewczuk; Waldemar Kazberuk; Wlodzimierz J Musial
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  24     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-07     Completed Date:  2008-08-29     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  633-9     Citation Subset:  IM    
Department of Cardiology, University Hospital in Bialystok, Poland.
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MeSH Terms
Albumins / diagnostic use
Angioplasty, Balloon, Coronary*
Combined Modality Therapy
Contrast Media / administration & dosage
Coronary Angiography*
Coronary Circulation / physiology*
Coronary Restenosis / diagnosis*,  physiopathology
Fluorocarbons / diagnostic use
Follow-Up Studies
Image Enhancement*
Image Processing, Computer-Assisted*
Microcirculation / physiology
Middle Aged
Myocardial Contraction / physiology
Myocardial Infarction / diagnosis,  physiopathology,  therapy*
Sensitivity and Specificity
Stroke Volume / physiology
Treatment Outcome
Ventricular Dysfunction, Left / diagnosis,  physiopathology
Reg. No./Substance:
0/Albumins; 0/Contrast Media; 0/FS 069; 0/Fluorocarbons

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