Document Detail


Myocardial perfusion as assessed by positron emission tomography during long-term mechanical circulatory support.
MedLine Citation:
PMID:  16596039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although mechanical circulatory support (MCS) can improve myocardial function in patients with advanced heart failure, its effects on relative myocardial perfusion are unclear. Using positron emission tomographic imaging techniques, the authors assessed relative myocardial perfusion in patients with ischemic or idiopathic cardiomyopathy who were receiving chronic MCS with a left ventricular assist device (pulsatile HeartMate [n = 2] [Thoratec Corporation, Pleasanton, CA] or nonpulsatile Jarvik 2000 [n = 4] [Jarvik Heart, Inc., New York, NY]). Relative myocardial perfusion was compared at lower and higher levels of MCS (50 vs. 100 - 110 ejections/min for the HeartMate and 8000 vs. 12,000 rpm for the Jarvik 2000). The size and severity of perfusion defects at rest and after dipyridamole stress were measured objectively and subjectively by computer algorithms and visual inspection, respectively. Relative myocardial perfusion increased > 5% from baseline in only one of six patients when MCS was increased. No change in relative myocardial perfusion of > 5% was seen in any of the other five patients, even after subsequent dipyridamole stress positron emission tomographic imaging. These pilot study findings suggest that the decreased metabolic requirements induced by ventricular unloading correspondingly decreased blood flow requirements to physiologically inactive myocardium.
Authors:
George V Letsou; Stefano Sdringola; Igor D Gregoric; Vijay Patel; Timothy J Myers; Reynolds M Delgado; O H Frazier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  12     ISSN:  1527-5299     ISO Abbreviation:  Congest Heart Fail     Publication Date:    2006 Mar-Apr
Date Detail:
Created Date:  2006-04-05     Completed Date:  2006-06-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-74     Citation Subset:  IM    
Affiliation:
Department of Cardiothoracic and Vasculay, The University of Texas-Houston Medical School, Houston, TX, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cardiomyopathies / radionuclide imaging*
Dipyridamole
Exercise Test
Female
Heart Ventricles / radionuclide imaging*
Heart-Assist Devices*
Humans
Male
Middle Aged
Myocardial Ischemia / radionuclide imaging*
Myocardial Reperfusion*
Perfusion*
Pilot Projects
Positron-Emission Tomography*
Time Factors
Chemical
Reg. No./Substance:
58-32-2/Dipyridamole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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