| Myocardial performance after successful intervention for native aortic coarctation. | |
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MedLine Citation:
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PMID: 20067654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coarctation of the aorta is associated with increased risk for hypertension in adulthood, despite successful repair. The intrinsic mechanisms underscoring hypertension and left ventricular performance in these patients, however, remains to be determined. Our objective was to evaluate left ventricular performance by means of echocardiographic and biochemical parameters at midterm follow-up in normotensive children who have had undergone successful surgical or catheter interventional treatment of coarctation with a residual gradient of less than 20 mmHg at rest. We studied prospectively 14 patients with native aortic coarctation who underwent surgery or balloon angioplasty, the cohort made up of equal numbers of boys and girls, and having a mean age of 8.5 plus or minus 4 years. We also studied 30 age-matched healthy subjects, measuring mitral inflow pulsed wave signals, isovolumic relaxation and contraction times, myocardial performance index parameters, and levels of B-type natriuretic peptide and endothelin-1 in both groups. We found no differences in systolic blood pressure at rest between the patients and their controls. The ventricular septal diastolic dimensions, left ventricular posterior wall dimensions, mitral valve E wave, deceleration time, isovolumic relaxation time, isovolumic contraction time and myocardial performance index were all significantly increased in the patients. Levels of plasma B-type natriuretic peptide and endothelin-1 were also significantly higher in the patients when compared to the control group. We conclude that aortic coarctation is a chronic disease characterized by persistency of myocardial and vascular alterations. The elevated levels of plasma b-type natriuretic peptide and endothelin-1 may be indicative of late onset hypertension after successful treatment of native coarctation in early childhood. |
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Authors:
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Vedide Tavli; Turkay Saritas; Baris Guven; Faik Okur; Berna Cevik Saylan; Talat Tavli; Bekir Sami Uyanik; Zeki Ari; Banu Isbilen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2010-01-13 |
Journal Detail:
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Title: Cardiology in the young Volume: 20 ISSN: 1467-1107 ISO Abbreviation: Cardiol Young Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-30 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200019 Medline TA: Cardiol Young Country: England |
Other Details:
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Languages: eng Pagination: 33-8 Citation Subset: IM |
Affiliation:
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Izmir Dr Behcet Uz Children's Hospital, Pediatric Cardiology, Izmir, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Angioplasty, Balloon / adverse effects, methods* Aortic Coarctation / therapy*, ultrasonography Biological Markers / blood Blood Pressure Determination Cardiac Surgical Procedures / adverse effects, methods Child Diastole / physiology Echocardiography, Doppler Endothelin-1 / blood* Endothelium, Vascular / pathology Female Follow-Up Studies Heart Catheterization / methods Heart Function Tests Humans Hypertrophy, Left Ventricular / etiology, ultrasonography* Male Myocardial Contraction / physiology* Natriuretic Peptide, Brain / blood* Observer Variation Probability Prospective Studies Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Endothelin-1; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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