Document Detail

Myocardial and pancreatic lesions induced by T-2 toxin, a trichothecene mycotoxin, in swine.
MedLine Citation:
PMID:  3727316     Owner:  NLM     Status:  MEDLINE    
Myocardial and pancreatic lesions induced by sublethal doses of T-2 toxin in swine were characterized by light and electron microscopy. Toxin was given intravenously to six 17- to 18-week-old pigs. Pigs were killed 24 or 48 hours after treatment. Grossly, subendocardial hemorrhages, multifocal pinpoint white foci in myocardium, and pancreatic edema occurred in one treated pig. Histologic changes in myocardium of treated pigs consisted of multifocal edema, mononuclear cell infiltration, myofiber hyalinization, vacuolation, and contraction bands with nuclear pyknosis. Ultrastructurally, there were areas of edema, myofibrillar disorganization, dilation of sarcoplasmic reticulum, and formation of hypercontraction bands. Myocardial mineralization was seen in the pig with gross lesions. Pancreatic changes in treated pigs consisted of multifocal acinar degeneration and necrosis. Ultrastructural changes included irregular dilation of rough endoplasmic reticulum and abnormal zymogen granules. Thus, in addition to radiomimetic lesions of the gastrointestinal tract and lymphoid organs, heart and pancreas are target organs of T-2 toxin in swine.
V F Pang; J H Adams; V R Beasley; W B Buck; W M Haschek
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Veterinary pathology     Volume:  23     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-08-01     Completed Date:  1986-08-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  310-9     Citation Subset:  IM    
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MeSH Terms
Microscopy, Electron
Myocardium / pathology*,  ultrastructure
Pancreas / pathology*,  ultrastructure
Sesquiterpenes / poisoning*
Swine Diseases / chemically induced*,  pathology
T-2 Toxin / poisoning*
Reg. No./Substance:
0/Sesquiterpenes; 21259-20-1/T-2 Toxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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