Document Detail


Myocardial oxygen tension in isolated erythrocyte-perfused rat hearts and comparison with crystalloid media.
MedLine Citation:
PMID:  9344779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The isolated heart, typically perfused with crystalloid media equilibrated with >/=95% O2 to ensure adequate myocardial oxygen tension, is commonly used to study cardiac function. When hemoglobin is available for oxygen transport, equilibration with 21% O2 is considered adequate to meet metabolic demands. This study presents the measurement of myocardial pO2 in isolated hearts perfused with an erythrocyte suspension. Baseline myocardial pO2 in erythrocyte-perfused hearts was 16.4+/-3.5 mmHg (mean+/-s.e.). When compared to previous measurements of myocardial pO2 in isolated hearts perfused with crystalloid media, the use of erythrocyte suspensions resulted in a 10-fold lower level of myocardial pO2, while avoiding very low and high values. The standard use of 95% oxygen with crystalloid results in myocardial levels of oxygen far above those usually found in the presence of hemoglobin and room air.
Authors:
B J Friedman; O Y Grinberg; S A Grinberg; H M Swartz
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  29     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-02-03     Completed Date:  1998-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2855-8     Citation Subset:  IM    
Copyright Information:
Copyright 1997 Academic Press Limited.
Affiliation:
Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Erythrocytes / physiology*
Isotonic Solutions
Male
Myocardium / metabolism*
Oxygen / metabolism*
Oxygen Consumption
Perfusion
Plasma Substitutes / pharmacology*
Rats
Rats, Wistar
Grant Support
ID/Acronym/Agency:
GM 51630/GM/NIGMS NIH HHS; RR 11602/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Isotonic Solutions; 0/Plasma Substitutes; 0/crystalloid solutions; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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