Document Detail


Myocardial oxygen consumption and substrate uptake in man during physiological and pathological volume load.
MedLine Citation:
PMID:  140676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is shown in trained and untrained healthy individuals that the energy requirement of the physiologically hypertrophied heart is lower at rest and even more pronounced during submaximal heavy exercise compared to the non-hypertrophied state. This difference exceeds the changes which could have been anticipated by deviations in hemodynamics and total heart weight. In patients with mild or moderate aortic insufficiency the energy expenditure of the pathologically hypertrophied heart per unit tissue mass is comparable to the non-hypertrophied state at rest or during exercise. It is increased in severe aortic regurgitation or additional myocarditis. The transition from compensation to failure may be associated with a steep decreased of the metabolic and flow reserve of the whole heart.
Authors:
H W Heiss; K Wink; J Barmeyer; J Keul; H Reindell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Basic research in cardiology     Volume:  72     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1977 Mar-Jun
Date Detail:
Created Date:  1977-06-30     Completed Date:  1977-06-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cardiomegaly / metabolism*
Humans
Myocarditis / metabolism
Myocardium / metabolism*,  pathology
Organ Size
Oxygen Consumption*
Physical Exertion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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