Document Detail

Myocardial oxygen consumption after reversible ischemia.
MedLine Citation:
PMID:  8069037     Owner:  NLM     Status:  MEDLINE    
There is a marked dissociation between return of contractile function and oxidative metabolism in stunned myocardium. Initial observations in isovolumically contracting hearts demonstrated that postischemically, the MVO2 to generate a given peak-developed pressure was augmented compared to preischemia. This metabolic inefficiency was independent of coronary hyperemia and myocellular oxygen extraction and not evident in the vented, empty beating state. In an ejecting heart model, the highly linear relationship between external mechanical work (integrated area of dynamic pressure-volume loops) increased non-working oxygen needs not to the efficiency of ejecting a given stroke volume. More sophisticated mathematical modeling to further compartmentalize chemomechanical transduction in the globally stunned heart has confirmed deranged energetics, but ascribing specific work components to inefficient oxygen need is predicated on the biological validity of each model. The findings in regionally stunned myocardium are more uniform, demonstrating paradoxically normal oxygen consumption despite persistent systolic bulging or markedly decreased systolic shortening. The relatively increased MVO2 in stunned hearts is not due to uncoupling of oxidative phosphorylation, but inefficient cellular ATP utilization.
N A Silverman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiac surgery     Volume:  9     ISSN:  0886-0440     ISO Abbreviation:  J Card Surg     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-09-29     Completed Date:  1994-09-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8908809     Medline TA:  J Card Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  465-8     Citation Subset:  IM    
Division of Cardiac and Thoracic Surgery, Henry Ford Hospital, Detroit, MI 48202.
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MeSH Terms
Adenosine Triphosphate / metabolism
Myocardial Stunning / metabolism*
Myocardium / metabolism*
Oxygen Consumption*
Reg. No./Substance:
56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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