Document Detail


Myocardial necrosis induced by breeding in stroke-prone/SHR.
MedLine Citation:
PMID:  7210076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Virgin and breeder, spontaneously hypertensive and stroke prone rats (SHR/SP) were observed from weaning until 130 +/- 10 days of age. Blood pressure rose rapidly, reaching 230--240 mm Hg. After the birth of the second litter of pups, male and female breeders began to die suddenly, due to myocardial necrosis and congestive heart failure. At autopsy, the brains of virgin and breeder SHR/SP were swollen but were free of any pathologic changes. There were no significant alterations in the blood chemistry of virgin rats but breeder SHR/SP had super-normal enzyme levels, CPK, SGOT, SGPT and LDH, hyperglycemia, hyperlipidemia, and hypersecretion of corticosterone. Breeder SHR/SP developed PAN-like lesions of the mesenteric arcades and adrenal cortex along with severe fibrino-hyalin lesions of the testicular and ovarian arteries. It is suggested that alterations in hypothalamic-pituitary-adrenal function associated with the reproductive effort conditioned these SHR/SP to develop myocardial necrosis rather than stroke and the development of unusual hypertensive arteriopathy.
Authors:
B C Wexler
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  11     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:    1980 Nov-Dec
Date Detail:
Created Date:  1981-05-21     Completed Date:  1981-05-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  665-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / blood
Animals
Aspartate Aminotransferases / blood
Blood Pressure
Breeding
Cerebrovascular Disorders / genetics
Corticosterone / blood
Creatine Kinase / blood
Disease Susceptibility
Female
Heart Failure / etiology
Hyperglycemia / etiology
Hyperlipidemias / etiology
Hypertension / genetics*,  physiopathology
L-Lactate Dehydrogenase / blood
Male
Myocardium / pathology*
Necrosis
Rats
Rats, Inbred Strains
Sexual Abstinence
Grant Support
ID/Acronym/Agency:
AG-585/AG/NIA NIH HHS; HL-21418/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
50-22-6/Corticosterone; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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