| Myocardial necrosis induced by breeding in stroke-prone/SHR. | |
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MedLine Citation:
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PMID: 7210076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Virgin and breeder, spontaneously hypertensive and stroke prone rats (SHR/SP) were observed from weaning until 130 +/- 10 days of age. Blood pressure rose rapidly, reaching 230--240 mm Hg. After the birth of the second litter of pups, male and female breeders began to die suddenly, due to myocardial necrosis and congestive heart failure. At autopsy, the brains of virgin and breeder SHR/SP were swollen but were free of any pathologic changes. There were no significant alterations in the blood chemistry of virgin rats but breeder SHR/SP had super-normal enzyme levels, CPK, SGOT, SGPT and LDH, hyperglycemia, hyperlipidemia, and hypersecretion of corticosterone. Breeder SHR/SP developed PAN-like lesions of the mesenteric arcades and adrenal cortex along with severe fibrino-hyalin lesions of the testicular and ovarian arteries. It is suggested that alterations in hypothalamic-pituitary-adrenal function associated with the reproductive effort conditioned these SHR/SP to develop myocardial necrosis rather than stroke and the development of unusual hypertensive arteriopathy. |
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Authors:
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B C Wexler |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 11 ISSN: 0039-2499 ISO Abbreviation: Stroke Publication Date: 1980 Nov-Dec |
Date Detail:
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Created Date: 1981-05-21 Completed Date: 1981-05-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 665-71 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Animals Aspartate Aminotransferases / blood Blood Pressure Breeding Cerebrovascular Disorders / genetics Corticosterone / blood Creatine Kinase / blood Disease Susceptibility Female Heart Failure / etiology Hyperglycemia / etiology Hyperlipidemias / etiology Hypertension / genetics*, physiopathology L-Lactate Dehydrogenase / blood Male Myocardium / pathology* Necrosis Rats Rats, Inbred Strains Sexual Abstinence |
| Grant Support | |
ID/Acronym/Agency:
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AG-585/AG/NIA NIH HHS; HL-21418/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-22-6/Corticosterone; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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