| Myocardial morphometric changes related to decreased contractility after endotoxin. | |
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MedLine Citation:
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PMID: 8967388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Decreased ventricular contractility during sepsis lasts much longer than the half-lives of inflammatory mediators that have been suggested to be myocardial depressant factors. Our hypothesis is that blood-borne factors may also cause myocardial structural changes, including damage and death of myocytes, associated with decreased ventricular contractility. We tested this hypothesis in an isolated rabbit heart perfused by a support rabbit. Support rabbits received 1 mg/kg endotoxin i.v. over 30 min (endotoxin group, n = 7) or vehicle (control group, n = 6). The slope of the end-systolic pressure-volume relationship, Emax, was used to measure contractility of the isolated heart. Five hours after endotoxin infusion, Emax decreased by 17 +/- 7% (P < 0.03) compared with 0 +/- 2% in the control group. Quantitative morphometric analysis of isolated hearts from the endotoxin group demonstrated an increased volume fraction of myocardial capillaries occupied by leukocytes (15.7 +/- 3.5 vs. 3.0 +/- 0.7% in the control group, P < 0.05), structurally abnormal myocytes (7.6 +/- 3.6 vs. 0.8 +/- 0.4%, P < 0.05), and interstitial edema (23.2 +/- 5.2 vs. 14.3 +/- 2.1%, P < 0.05). We conclude that blood-borne factors cause myocardial structural changes that may contribute to decreased ventricular contractility and may explain the prolonged decrease in ventricular contractility during sepsis. |
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Authors:
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C M Goddard; M F Allard; J C Hogg; K R Walley |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 270 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-12-04 Completed Date: 1996-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1446-52 Citation Subset: IM |
Affiliation:
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Pulmonary Research Laboratory, St. Paul's Hospital, University of British Columbia, Vancouver, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Volume / drug effects Coronary Circulation Endotoxins / pharmacology* Female Heart / drug effects Heart Rate / drug effects Leukocyte Count / drug effects Leukocytes / physiology Male Myocardial Contraction / drug effects* Myocardium / pathology* Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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