| Myocardial microvascular perfusion after transfusion of liposome-encapsulated hemoglobin evaluated in cross-circulated rat hearts using tracer digital radiography. | |
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MedLine Citation:
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PMID: 15558336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of hemodilution with Neo Red Cell (NRC, liposome-encapsulated hemoglobin) on myocardial perfusion was evaluated in cross-circulated rat hearts under 300-bpm pacing and 100-mmHg perfusion pressure. In NRC-transfused hearts (n = 5), NRC volume fraction and hematocrit were 9% +/- 3% and 22% +/- 4%, respectively; the latter decreased from 43% +/- 3% before NRC transfusion. Coronary perfusion rate and left ventricular isovolemic developed pressure increased after NRC transfusion to 4.6 +/- 1.0 ml/min/g and 127 +/- 32 mmHg from basal values of 2.5 +/- 0.3 ml/min/g and 115 +/- 28 mmHg, respectively. In contrast, the flow increase during reperfusion following 30-s flow cessation decreased from 74% +/- 24% to 64% +/- 24%. The arteriovenous difference in O2 saturation was slightly higher after NRC transfusion. Within-layer regional flow distributions from subepicardium to subendocardium assessed by tracer digital radiography (100-microm resolution) showed that coefficients of variation of flows in 400 x 400-microm regions were 0.41 +/- 0.10 in NRC-transfused hearts and 0.54 +/- 0.11 in nontransfused hearts (n = 5); i.e., the myocardial flow distribution was more uniform in NRC-transfused hearts. These results suggest that NRC is superior to erythrocytes in terms of the homogenization of O2 delivery, indicating its potential therapeutic value in myocardial microcirculatory failure. |
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Authors:
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Takahisa Asano; Takeshi Matsumoto; Hiroyuki Tachibana; Mami Takemoto; Fumihiko Kajiya |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs Volume: 7 ISSN: 1434-7229 ISO Abbreviation: J Artif Organs Publication Date: 2004 |
Date Detail:
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Created Date: 2004-11-23 Completed Date: 2005-03-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815648 Medline TA: J Artif Organs Country: Japan |
Other Details:
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Languages: eng Pagination: 145-8 Citation Subset: IM |
Affiliation:
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Department of Medical Engineering and Systems Cardiology, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan. taasano@med.kawasaki-m.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Substitutes* Cross Circulation Heart / physiology* Hemoglobins Hemorheology Liposomes Microcirculation / physiology Oxygen Consumption Radiographic Image Enhancement Rats |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Hemoglobins; 0/Liposomes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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