Document Detail


Myocardial microangiopathy associated with antiphospholipid antibodies.
MedLine Citation:
PMID:  11237124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myocardial thrombotic microangiopathy is a well described post-mortem finding in patients with the catastrophic antiphospholipid (APL) syndrome. However, it has been only very rarely imaged in living patients. Here, we report two patients with APL antibodies presenting with scintigraphic, electrocardiographic and/or echocardiographic evidence of (sub)acute myocardial ischaemia, despite a normal coronary angiography. Formal proof of a thrombotic microangiopathy was obtained by a kidney biopsy in one patient. We emphasize the value of 99mTc-MIBI (2-methoxy isobutyl isonitrile) exercise stress myocardial scintigraphy for the detection of cardiac microangiopathy associated with the APL syndrome.
Authors:
B R Lauwerys; M Lambert; J L Vanoverschelde; J P Cosyns; F A Houssiau
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Lupus     Volume:  10     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2001  
Date Detail:
Created Date:  2001-03-09     Completed Date:  2001-06-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  123-5     Citation Subset:  IM    
Affiliation:
Rheumatology Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Antiphospholipid*
Antiphospholipid Syndrome*
Coronary Disease*
Female
Humans
Chemical
Reg. No./Substance:
0/Antibodies, Antiphospholipid

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