Document Detail

Myocardial metabolism during fixed-rate pulsatile left ventricular bypass.
MedLine Citation:
PMID:  2078546     Owner:  NLM     Status:  MEDLINE    
Fixed-rate pulsatile cardiopulmonary bypass may improve subendocardial perfusion during ventricular fibrillation and has been employed during intermittent aortic cross-clamping. Variable-rate pulsatile left heart bypass that is governed by venous inflow and is asynchronous to the electrical activity of the heart is currently used in clinical practice. To study the effect of fixed-rate pulsation on myocardial metabolism during left heart bypass, six adult pigs underwent alternating periods of pulsatile (PLS) and nonpulsatile (NPLS) centrifugal pump left atrial-to-aortic bypass in randomized block design. Coronary sinus, aortic, and bypass circuit flows were recorded. Oxygen content and lactate concentration of coronary sinus and aortic blood were measured. Pulsatility index and pulse power index during pulsatile bypass were 4.4 and 4.7 (cycles/s)2, respectively. Percent bypass was maximal at a mean pulsation rate of 41.3 and averaged 92.2 and 91.3 for PLS and NPLS, respectively. Myocardial oxygen consumption per minute was reduced 14.3% during NPLS but was unchanged during PLS compared to control (CTRL). Percent lactate extraction was significantly lower than CTRL during NPLS only. Competition for inflow with the ejecting heart appeared to limit circuit pulsation rate and pulse power index. Fixed-rate pulsation is ineffective in reducing myocardial metabolism and should be avoided in left heart bypass.
D C Kress; I Pasaoglu; D J Cohen; D K Swanson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  3     ISSN:  0894-1939     ISO Abbreviation:  J Invest Surg     Publication Date:  1990  
Date Detail:
Created Date:  1991-04-30     Completed Date:  1991-04-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  235-43     Citation Subset:  IM    
Division of Cardiothoracic Surgery, University of Wisconsin Hospitals and Clinics, Madison 53792.
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MeSH Terms
Heart Ventricles
Heart-Assist Devices*
Myocardium / metabolism*
Oxygen Consumption

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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