| Myocardial metabolic and morphometric changes during canine endotoxin shock before and after glucose-insulin-potassium. | |
| | |
MedLine Citation:
|
PMID: 3899358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Glucose-insulin-potassium (GIK) improves myocardial function during endotoxin shock but the mechanism of this action is not clear. We have studied in open chest dogs the effects of GIK (n = 9) on haemodynamics, myocardial biochemistry (repeated drill biopsies; glucose-6-phosphate, G-6-P; fructose-6-phosphate, F-6-P; adenosine triphosphate, ATP; creatinine phosphate, CP; glycogen) and myocardial histomorphometry. The animals were anaesthetised (etomidate 4 mg X kg-1 X h-1) and artificially ventilated (N2O:O2 = 2:1). After endotoxin (1.5 mg X kg-1) cardiac output (CO) and mean arterial pressure (MAP) fell rapidly, with a temporary recovery followed by gradual circulatory collapse. Coronary blood flow (cbf; radioactive microspheres) decreased, but this was not significant. G-6-P tended to fall, as did ATP levels while CP levels were unaltered. Histomorphometrical analysis showed myocardial cell swelling with compression of capillaries and decreased interstitial volume. GIK infusion (50% glucose, 2 g X kg-1bw, 8 mmol KCl and 3 U insulin kg-1bw) increased CO and coronary blood flow. Glycogen and G-6-P levels did not change, while F-6-P tended to increase. ATP levels were not influenced by ATP/CP ratio decreased. Myocardial cell swelling markedly decreased; average capillary cross-sectional area, as an index of capillary compression, returned to control value. In two dogs, which died before the end of the experiment, myocardial oedema, with disturbed capillary volume and reduced interstitial volume was unaltered after GIK. The initial effects of GIK are most likely due to restoration of myocardial perfusion. Improved perfusion, and the influence of elevated serum osmolality and insulin levels on excitation-contraction coupling may help to improve myocardial function. |
| | |
Authors:
|
W Bronsveld; A A van Lambalgen; D van Velzen; G C van den Bos; P A Koopman; L G Thijs |
Related Documents
:
|
7924378 - Quantitated left ventricular systolic mechanics in children with septic shock utilizing... 19601398 - Physical influences on right ventricular infarction and cardiogenic shock in acute myoc... 1999638 - Value of ventricular electrogram recordings in the diagnosis of arrhythmias precipitati... 7354738 - Comparison of myocardial damage from defibrillator discharges at various dosages. 7924378 - Quantitated left ventricular systolic mechanics in children with septic shock utilizing... 18459468 - Antegrade visualisation of the coronary sinus for left ventricular pacing. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cardiovascular research Volume: 19 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1985 Aug |
Date Detail:
|
Created Date: 1985-11-04 Completed Date: 1985-11-04 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 455-64 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Capillaries / pathology Coronary Circulation / drug effects Dogs Glucose / metabolism, pharmacology* Insulin / pharmacology* Lactates / metabolism Myocardium / metabolism*, pathology Oxygen Consumption / drug effects Potassium / pharmacology* Shock, Septic / metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
|
0/Lactates; 0/glucose-insulin-potassium cardioplegic solution; 11061-68-0/Insulin; 50-99-7/Glucose; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ante-and postnatal evaluation of the Dandy-Walker syndrome.
Next Document: Characterisation of aorto-iliac arterial stenoses in terms of pressure and flow.