Document Detail

Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function.
MedLine Citation:
PMID:  17928585     Owner:  NLM     Status:  MEDLINE    
It is now becoming apparent that dynamic changes occur within the interstitium that directly contribute to adverse myocardial remodeling following myocardial infarction (MI), with hypertensive heart disease and with intrinsic myocardial disease such as cardiomyopathy. Furthermore, a family of matrix proteases, the matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs), has been recognized to play an important role in matrix remodeling in these cardiac disease states. The purpose of this review is fivefold: 1) to examine and redefine the myocardial matrix as a critical and dynamic entity with respect to the remodeling process encountered with MI, hypertension, or cardiomyopathic disease; 2) present the remarkable progress that has been made with respect to MMP/TIMP biology and how it relates to myocardial matrix remodeling; 3) to evaluate critical translational/clinical studies that have provided a cause-effect relationship between alterations in MMP/TIMP regulation and myocardial matrix remodeling; 4) to provide a critical review and analysis of current diagnostic, prognostic, and pharmacological approaches that utilized our basic understanding of MMP/TIMPs in the context of cardiac disease; and 5) most importantly, to dispel the historical belief that the myocardial matrix is a passive structure and supplant this belief that the regulation of matrix protease pathways such as the MMPs and TIMPs will likely yield a new avenue of diagnostic and therapeutic strategies for myocardial remodeling and the progression to heart failure.
Francis G Spinale
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Physiological reviews     Volume:  87     ISSN:  0031-9333     ISO Abbreviation:  Physiol. Rev.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-11     Completed Date:  2007-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231714     Medline TA:  Physiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1285-342     Citation Subset:  IM    
Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina 29403, USA.
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MeSH Terms
Extracellular Matrix / enzymology*,  physiology
Gene Expression / physiology
Heart / anatomy & histology,  physiology
Heart Diseases / enzymology,  pathology,  physiopathology
Matrix Metalloproteinases / genetics,  metabolism*
Myocardium / enzymology*
Ventricular Remodeling / physiology*
Grant Support
Reg. No./Substance:
EC 3.4.24.-/Matrix Metalloproteinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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