Document Detail

Myocardial lysis in a fetus induced by maternal paraphenylenediamine poisoning following an intentional ingestion to induce abortion.
MedLine Citation:
PMID:  18715891     Owner:  NLM     Status:  MEDLINE    
The acute toxicity of paraphenylenediamine (PPD) has been associated with several histopathological changes. In humans, acute PPD poisoning is known to cause rhabdomyolisis and particularly myocardial lysis. However, its toxicity for the fetus has never been reported in the literature. We report a case of myocardial lysis in a fetus expelled by a 22-year-old mother after apparent ingestion of an unknown amount of PPD. The patient was admitted to our intensive care unit with acute onset of respiratory distress and rhabdomyolysis. The pelvic ultrasonography on admission showed a normally progressing pregnancy of 23-24 weeks. On day 9 post-ingestion, the patient spontaneously expelled a non-viable fetus. The fetal examination did not show any external or macroscopic abnormalities. However, the histopathological exam showed an important heart and lung congestion. There was also some interstitial edema and inflammation at the base of the lingua, in addition to a chorionic villus thrombosis and abruptio placentae. The histopathology of the myocardium showed lysis of the cardiac muscle. This observation suggests that the PPD was most likely responsible for the myocardial injury in the fetus.
K Abidi; B Himdi; N Cherradi; N Lamalmi; Z Alhamany; Aa Zeggwagh; R Abouqal
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  27     ISSN:  0960-3271     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-08-21     Completed Date:  2008-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  435-8     Citation Subset:  IM    
Emergency and Medical ICU, Ibn Sina University Hospital, CHU Ibn Sina, Rabat, Morocco.
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MeSH Terms
Abortion, Criminal*
Administration, Oral
Coloring Agents / adverse effects*
Fatal Outcome
Fetal Diseases / chemically induced*,  pathology
Gestational Age
Heart / drug effects*,  embryology
Maternal Exposure
Maternal-Fetal Exchange
Myocarditis / chemically induced*,  embryology,  pathology
Myocardium / pathology
Phenylenediamines / adverse effects*
Reg. No./Substance:
0/Coloring Agents; 0/Phenylenediamines; 106-50-3/4-phenylenediamine

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