Document Detail

Myocardial ischemia and stunning induced by topical intranasal phenylephrine pledgets.
MedLine Citation:
PMID:  9433094     Owner:  NLM     Status:  MEDLINE    
This case study describes myocardial ischemia and stunning after the topical application of phenylephrine-soaked pledgets (0.25%) in a 63-year-old female undergoing elective endoscopic sinus surgery. The patient had no previous history of cardiovascular disease or illicit drug use. Transient myocardial ischemia was associated with acute hypertension, chest pain, and S-T segment changes 4 minutes after pledget placement. Angiography revealed normal coronary blood flow and severe left ventricular systolic and diastolic dysfunction. Follow-up echocardiography demonstrated improved left ventricular function within 1 week and total resolution of dysfunction by 4 weeks after ischemia.
R B Hecker; J V Hays; J D Champ; B J Rubal
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Military medicine     Volume:  162     ISSN:  0026-4075     ISO Abbreviation:  Mil Med     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-02-09     Completed Date:  1998-02-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2984771R     Medline TA:  Mil Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  832-5     Citation Subset:  IM    
Anesthesia and Operative Service, Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200, USA.
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MeSH Terms
Administration, Intranasal
Adrenergic alpha-Agonists / administration & dosage,  adverse effects*
Middle Aged
Myocardial Ischemia / chemically induced*
Myocardial Stunning / chemically induced*
Phenylephrine / administration & dosage,  adverse effects*
Sinusitis / surgery
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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