Document Detail

Myocardial ischemia-reperfusion injury: a neglected therapeutic target.
MedLine Citation:
PMID:  23281415     Owner:  NLM     Status:  MEDLINE    
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention (PPCI). However, the process of reperfusion can itself induce cardiomyocyte death, known as myocardial reperfusion injury, for which there is still no effective therapy. A number of new therapeutic strategies currently under investigation for preventing myocardial reperfusion injury have the potential to improve clinical outcomes in patients with acute MI treated with PPCI.
Derek J Hausenloy; Derek M Yellon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-02
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-03-11     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  92-100     Citation Subset:  AIM; IM    
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MeSH Terms
Cell Death
Myocardial Infarction / complications,  metabolism,  pathology,  physiopathology*,  therapy*
Myocardial Reperfusion Injury / etiology,  metabolism,  pathology,  physiopathology*,  prevention & control*
Myocytes, Cardiac / metabolism,  pathology
Percutaneous Coronary Intervention*
Thrombolytic Therapy*
Grant Support
FS/06/023//British Heart Foundation; MR/K002066/1//Medical Research Council; RG/03/007//British Heart Foundation; RG/08/015/26411//British Heart Foundation; //Department of Health

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