| Myocardial ischemia-reperfusion injury: a neglected therapeutic target. | |
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MedLine Citation:
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PMID: 23281415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention (PPCI). However, the process of reperfusion can itself induce cardiomyocyte death, known as myocardial reperfusion injury, for which there is still no effective therapy. A number of new therapeutic strategies currently under investigation for preventing myocardial reperfusion injury have the potential to improve clinical outcomes in patients with acute MI treated with PPCI. |
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Authors:
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Derek J Hausenloy; Derek M Yellon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2013-01-02 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 123 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-02 Completed Date: 2013-03-11 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 92-100 Citation Subset: AIM; IM |
Affiliation:
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Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London WC1E 6HX, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Death Humans Myocardial Infarction / complications, metabolism, pathology, physiopathology*, therapy* Myocardial Reperfusion Injury / etiology, metabolism, pathology, physiopathology*, prevention & control* Myocytes, Cardiac / metabolism, pathology Percutaneous Coronary Intervention* Thrombolytic Therapy* |
| Grant Support | |
ID/Acronym/Agency:
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FS/06/023//British Heart Foundation; RG/03/007//British Heart Foundation; //Department of Health |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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