Document Detail

Myocardial ischemia related to ergot alkaloids: a case report and literature review.
MedLine Citation:
PMID:  1774159     Owner:  NLM     Status:  MEDLINE    
Ergotamine tartrate and methysergide are widely used headache treatments with important vasoconstrictive properties. We report a 31-year-old man with cluster headaches who developed severe, prolonged myocardial ischemia following combination therapy with ergotamine tartrate and methysergide. We reviewed the cardiovascular complications of each agent alone and in combination. Given the pharmacologic similarity of these agents, we propose that they may have additive or synergistic cardiac toxicity, at least in vulnerable individuals. We recommend caution when these agents are used together.
B S Galer; R B Lipton; S Solomon; L C Newman; E L Spierings
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Headache     Volume:  31     ISSN:  0017-8748     ISO Abbreviation:  Headache     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1992-03-03     Completed Date:  1992-03-03     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  446-50     Citation Subset:  IM    
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10467.
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MeSH Terms
Cluster Headache / drug therapy
Coronary Disease / chemically induced*
Drug Therapy, Combination
Ergot Alkaloids / adverse effects*,  therapeutic use
Methysergide / therapeutic use
Reg. No./Substance:
0/Ergot Alkaloids; 361-37-5/Methysergide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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