| Myocardial ischemia induces the release of substance P from cardiac afferent neurons in rat thoracic spinal cord. | |
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MedLine Citation:
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PMID: 14684370 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antibody-coated microprobes were inserted into the thoracic (T3-4) spinal cord in urethane-anesthetized Sprague-Dawley rats to detect the differences in the release of immunoreactive substance P-like (irSP) substances in response to differential activation of cardiac nociceptive sensory neurons (CNAN). CNAN were stimulated either by intrapericardial infusion of an inflammatory ischemic exudate solution (IES) containing algogenic substances (i.e., 10 mM each of adenosine, bradykinin, prostaglandin E2, and 5-hydroxytryptamine), or by transient occlusion of the left anterior descending coronary artery (CoAO). There was widespread basal release of irSP from the thoracic spinal cord. Stimulation of the CNAN by IES did not alter the pattern of release of irSP. Conversely, CoAO augmented the release of irSP from T3-4 spinal segments from laminae I-VII. This CoAO-induced irSP release was eliminated after thoracic dorsal rhizotomy. These results indicate that heterogeneous activation of cardiac afferents, as with focal coronary artery occlusion, represents an optimum input for activation of the cardiac neuronal hierarchy and for the resultant perception of angina. Excessive stimulation of cardiac nociceptive afferent neurons elicited during regional coronary artery occlusion involves the release of SP in the thoracic spinal cord and suggests that local spinal cord release of SP may be involved in the neural signaling of angina. |
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Authors:
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Fang Hua; Brian A Ricketts; Angela Reifsteck; Jeffrey L Ardell; Carole A Williams |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-12-18 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 286 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-09 Completed Date: 2004-05-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1654-64 Citation Subset: IM |
Affiliation:
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Department of Physiology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614-1708, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Disease / physiopathology Exudates and Transudates / metabolism Female Heart / innervation* Male Myocardial Ischemia / metabolism*, physiopathology Neurons, Afferent / metabolism* Nociceptors / physiopathology Rats Rats, Sprague-Dawley Spinal Cord / metabolism* Substance P / metabolism* Thoracic Vertebrae |
| Chemical | |
Reg. No./Substance:
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33507-63-0/Substance P |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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