Document Detail

Myocardial ischemia in cocaine-user with anomalous origin of the left circumflex coronary artery.
MedLine Citation:
PMID:  20707251     Owner:  NLM     Status:  MEDLINE    
The prevalence of anomalous coronary artery is approximately 0.6-1.7% in patients who undergo coronary angiography. These anomalies may cause angina, acute myocardial infarction, syncope and sudden death. Cocaine abuse is now a major health hazard: more than 5 million of Americans are current users. Cocaine abuse can result in coronary artery vasocostriction and the association between cocaine abuse, myocardial ischemia and infarction in the absence of coronary artery disease has been reported. We report the case of a patient with a story of nasally inhaled cocaine abuse presented with exertional chest pain and a perfusion defect of the anterior and inferior-lateral walls of the left ventricle during myocardial perfusion SPECT. The anomalous origin of the left circumflex coronary artery from the righ sinus of Valsalva was detected during coronary angiography and confirmed by the multislice computed tomography (MSCT). Although the coronary angiography is the gold standard of cardiac imaging technique for the diagnosis of coronary artery disease the identification of anomalous coronary arteries is frequently difficult with conventional coronary angiography because of the lack of 3-dimensional (3D) information related to the course of the coronary arteries to the great vessels. The MSCT provides a high spatial resolution, which allows a successful identification of the congenital coronary artery anomalies. This case report provides further a supportive evidence for the role of MSCT in the detection of the coronary artery anomalies.
N Alessandri; A Di Matteo; M Petrassi; F Tufano; L Lanzi; L Fusco; A D'Ambrosi
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European review for medical and pharmacological sciences     Volume:  14     ISSN:  1128-3602     ISO Abbreviation:  Eur Rev Med Pharmacol Sci     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9717360     Medline TA:  Eur Rev Med Pharmacol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  613-8     Citation Subset:  IM    
Department of Heart and Great Vessels A. Reale, polo pontino, University of Rome Sapienza, Rome, Italy.
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MeSH Terms
Administration, Intranasal
Cocaine / administration & dosage,  adverse effects
Cocaine-Related Disorders / complications*
Coronary Angiography / methods
Coronary Vessel Anomalies / complications,  diagnosis*
Myocardial Ischemia / chemically induced,  diagnosis*
Myocardial Perfusion Imaging / methods
Tomography, Emission-Computed, Single-Photon / methods
Tomography, X-Ray Computed / methods
Reg. No./Substance:

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