Document Detail

Myocardial ischemia detected by thallium scintigraphy is frequently related to cardiac arrest and syncope in young patients with hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  8102625     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The purpose of this study was to determine the frequency of myocardial ischemia as a potential mechanism for cardiac arrest and syncope in young patients with hypertrophic cardiomyopathy who experienced such complications. BACKGROUND: Sudden cardiac death and syncope occur frequently in patients with hypertrophic cardiomyopathy. Although ventricular arrhythmias account for most of these events in adult patients, the mechanism responsible for cardiac arrest and syncope in young patients has not been established. METHODS: Twenty-three patients with hypertrophic cardiomyopathy, aged 6 to 23 years, with previous cardiac arrest (n = 8), syncope (n = 7) or a family history of sudden cardiac death (n = 8) were evaluated to determine the prevalence of spontaneous ambulatory ventricular tachycardia (24- to 72-h electrocardiographic [ECG] monitoring), exercise-induced myocardial ischemia (thallium scintigraphy) and inducibility of ventricular tachycardia (electrophysiologic studies). RESULTS: Three of 15 patients with a history of cardiac arrest or syncope had ventricular tachycardia on ambulatory ECG monitoring. However, all 15 patients, had inducible ischemia by thallium scintigraphy compared with only 3 (37%) of 8 patients with no such history (p < 0.01). In contrast, ventricular tachycardia induction was uncommon in all of the young patients (27% in those with cardiac arrest or syncope; 0% in the others). During therapy for ischemia with verapamil alone or in combination with beta-adrenergic blocking agents, only 4 of the 15 patients with cardiac arrest or syncope had further episodes. In three of the four patients, these events were temporally related to discontinuation of verapamil. Among eight patients who had a repeat exercise thallium study while receiving anti-ischemic therapy, seven (88%) had improved regional thallium uptake, of whom three had normal thallium studies. CONCLUSIONS: These data suggest that in young patients with hypertrophic cardiomyopathy, sudden cardiac arrest or syncope is frequently related to ischemia rather than to a primary arrhythmogenic ventricular substrate.
V Dilsizian; R O Bonow; S E Epstein; L Fananapazir
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  22     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-09-23     Completed Date:  1993-09-23     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  796-804     Citation Subset:  AIM; IM    
Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Cardiac Pacing, Artificial
Cardiomyopathy, Hypertrophic / complications*,  therapy
Defibrillators, Implantable
Exercise Test / methods
Heart Arrest / epidemiology,  etiology*,  prevention & control
Myocardial Ischemia / complications,  epidemiology,  radionuclide imaging*,  therapy
Syncope / epidemiology,  etiology*,  prevention & control
Tachycardia, Ventricular / epidemiology,  etiology,  prevention & control
Thallium Radioisotopes / diagnostic use*
Tomography, Emission-Computed, Single-Photon / methods
Verapamil / therapeutic use
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Thallium Radioisotopes; 52-53-9/Verapamil
Comment In:
J Am Coll Cardiol. 1993 Sep;22(3):805-7   [PMID:  8354815 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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