| Myocardial ischemia, carotid, and peripheral arterial disease and their interrelationship in type 2 diabetes patients. | |
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MedLine Citation:
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PMID: 19685102 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in type 2 diabetes mellitus (T2DM) patients. We examined the relationship between CVD in different vascular territories. METHODS: T2DM patients without known or suspected CVD (n = 305) referred consecutively to a diabetes clinic for the first time and age-matched nondiabetic reference subjects (n = 40) were screened for myocardial ischemia, carotid, and peripheral arterial disease by means of myocardial perfusion scintigraphy, carotid artery ultrasonography, and peripheral ankle and toe systolic blood pressure measurements. RESULTS: In the T2DM patients, the prevalence of myocardial ischemia, carotid, and peripheral arterial disease was 30%, 42%, and 15%, respectively, almost three times higher than in the reference subjects (P = 0.007, P = 0.001, and P = 0.09, respectively). T2DM patients with myocardial ischemia, carotid, or peripheral arterial disease had a significantly increased risk of CVD in other vascular territories as well (OR: 1.99, 2.09, and 3.09, respectively). However, 40%, 52%, and 22% of the T2DM patients with myocardial ischemia, carotid, or peripheral arterial disease demonstrated exclusively this particular type of CVD manifestation. CONCLUSIONS: In T2DM patients, signs of CVD in one vascular territory carry a significantly increased risk of CVD in other territories, although many patients only presented one manifestation. |
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Authors:
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Mikael K Poulsen; Jan Erik Henriksen; Jordi Dahl; Allan Johansen; Jacob E M??ller; Oke Gerke; Werner Vach; Torben Haghfelt; Henning Beck-Nielsen; Poul Flemming H??ilund-Carlsen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-14 |
Journal Detail:
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Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: 16 ISSN: 1532-6551 ISO Abbreviation: J Nucl Cardiol Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-11-12 Completed Date: 2010-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 878-87 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Odense University Hospital, Kl??vervaenget 6, 5th Floor, 5000, Odense C, Denmark. doc_mkp@hotmail.com |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00298844 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carotid Artery Diseases
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epidemiology*,
radionuclide imaging* Comorbidity Denmark / epidemiology Diabetes Mellitus, Type 2 / epidemiology*, radionuclide imaging* Female Humans Male Middle Aged Myocardial Ischemia / epidemiology*, radionuclide imaging* Myocardial Perfusion Imaging / statistics & numerical data Peripheral Vascular Diseases / epidemiology*, radionuclide imaging* Prevalence Risk Assessment / methods Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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