Document Detail

Myocardial ischemia after orthotopic liver transplantation.
MedLine Citation:
PMID:  8017307     Owner:  NLM     Status:  MEDLINE    
A hypercoagulable state exists after orthotopic liver transplantation. This hematologic abnormality may predispose patients to coronary thrombosis and unstable angina. The incidence of postoperative myocardial ischemia in such patients is unknown. Suitable electrocardiograms and clinical events of consecutive patients undergoing orthotopic liver transplantation (n = 45) and major intraabdominal surgery (n = 28) during a 3-month period at a major university teaching hospital and transplant center were examined retrospectively. Clinical myocardial ischemia or ischemic electrocardiographic changes, or both, occurred in 6 transplant patients compared with no patient in the nontransplant or comparison group. In 4 of the 6 patients with dramatic electrocardiographic changes and ischemic events, coronary arteriography failed to demonstrate significant obstructive disease. It is concluded that severe myocardial ischemia may occur in patients after orthotopic liver transplantation in the absence of significant coronary disease. A hypercoagulable state may predispose to coronary thrombosis in this setting, providing insight (and a future model for study) into the development of unstable angina.
D A Rubin; D S Schulman; T D Edwards; T E Starzl; E I Curtiss
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  74     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-07-22     Completed Date:  1994-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-6     Citation Subset:  AIM; IM    
Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania.
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MeSH Terms
Abdomen / surgery
Blood Coagulation Disorders / complications
Liver Transplantation / adverse effects*
Middle Aged
Myocardial Ischemia / diagnosis,  etiology*
Retrospective Studies

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