Document Detail

Myocardial ischaemia and reperfusion injury: reactive oxygen species and the role of neutrophil.
MedLine Citation:
PMID:  16202368     Owner:  NLM     Status:  MEDLINE    
A growing body of evidence suggests that oxygen radicals can mediate myocardial tissue injury during ischaemia and, in particular, during reperfusion. This review focuses on the role of neutrophil as a mediator of myocardial damage. Upon reperfusion, neutrophils accumulate and produce an inflammatory response in the myocardium that is responsible, in part, for the extension of tissue injury associated with reperfusion. It has shown that the inhibition of neutrophil accumulation and adhesion is associated with decreased infarct size. This strongly suggests that myocardial cells at risk region undergo irreversible changes upon reperfusion and accumulation of neutrophils. Several pharmacological agents (ibuprofen, allopurinol, prostacyclin, and prostaglandin E analogues) protect the myocardium from reperfusion injury. In addition, the mechanisms by which these agents act and directions of research that may lead to therapeutically useful approaches are also discussed in this review.
Sheikh Arshad Saeed; Muhammad Anwar Waqar; Akbar Jaleel Zubairi; Hadi Bhurgri; Abdullah Khan; Saqib Ali Sikander Gowani; Saima N Waqar; M Iqbal Choudhary; Saima Jalil; Ali Hyder Zaidi; Iffat Ara
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP     Volume:  15     ISSN:  1022-386X     ISO Abbreviation:  J Coll Physicians Surg Pak     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-10-05     Completed Date:  2005-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606447     Medline TA:  J Coll Physicians Surg Pak     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  507-14     Citation Subset:  IM    
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
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MeSH Terms
Allopurinol / pharmacology
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Epoprostenol / pharmacology
Free Radical Scavengers / pharmacology
Ibuprofen / pharmacology
Iloprost / pharmacology
Myocardial Ischemia / physiopathology*
Myocardial Reperfusion Injury / physiopathology*,  prevention & control
Neutrophils / physiology*
Prostaglandins E, Synthetic / pharmacology
Reactive Oxygen Species / pharmacology
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Free Radical Scavengers; 0/Prostaglandins E, Synthetic; 0/Reactive Oxygen Species; 15687-27-1/Ibuprofen; 315-30-0/Allopurinol; 35121-78-9/Epoprostenol; 78919-13-8/Iloprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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