| Myocardial ischaemia: metabolic disorders leading to cell death. | |
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MedLine Citation:
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PMID: 7818937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experimental studies have demonstrated that reperfusion is associated with a host of distinctive pathophysiological derangements, among which the most important are reperfusion arrhythmias, transient mechanical dysfunction or "myocardial stunning", and cell death. Reperfusion arrhythmias and myocardial stunning occur in experimental animals after transient ischemia followed by reperfusion, and there is considerable evidence that they also develop in patients, although the existence of malignant reperfusion arrhythmias in humans remains uncertain. Both reperfusion arrhythmias and myocardial stunning can ben considered a manifestation of sublethal, reversible cellular injury. Although the pathogenesis of reperfusion arrhythmias and stunning has not been conclusively established, there is considerable evidence that generation of oxygen radicals and perturbations of calcium homeostasis play an important role. Accordingly, antioxidants or calcium antagonists have been shown to be beneficial in mitigating these manifestations of reperfusion injury. In contrast, the existence of a lethal reperfusion-induced injury remains highly controversial. Although many studies have reported reduction of infarct size with antioxidants, numerous other investigation have failed to reproduce these results. As a consequence, intense controversy persists regarding whether oxygen radicals contribute to extending cell death upon reperfusion and whether reperfusion in itself causes cell death. It is unlikely that such controversy will be resolved any time soon and that clinical therapies aimed at reducing reperfusion-induced cell death will become available in the near future. |
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Authors:
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R Bolli |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology Volume: 13 ISSN: 0870-2551 ISO Abbreviation: Rev Port Cardiol Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1995-02-16 Completed Date: 1995-02-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8710716 Medline TA: Rev Port Cardiol Country: PORTUGAL |
Other Details:
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Languages: eng Pagination: 649-53 Citation Subset: IM |
Affiliation:
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Section of Cardiology, Baylor College of Medicine, Houston. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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etiology Cell Death Humans Myocardial Infarction / complications, metabolism*, pathology Myocardial Reperfusion Injury / etiology Myocardial Stunning / etiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-42267/HL/NHLBI NIH HHS; HL-43151/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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