Document Detail

Myocardial ischaemia in asphyxia neonatorum. Electrocardiographic, enzymatic and histological correlations.
MedLine Citation:
PMID:  4024929     Owner:  NLM     Status:  MEDLINE    
Serial electrocardiograms and creatine kinase (CK) isoenzyme activities were studied prospectively in 20 asphyxiated term newborn infants and 43 normal neonates. By adapting a previously described grading system for ischaemic changes, a degree of electrocardiographic ischaemia was defined which occurred almost solely in asphyxiated infants. Infants with this degree of abnormality had significantly higher mean CK-MB and MM activities than other asphyxiated infants at 0, 8 and 28 hours. Histological changes of peripartum myocardial necrosis were seen in 4 of the 5 infants on whom an autopsy was performed, and either electrocardiogram or CK-MB was abnormal in all four. It is concluded that myocardial injury in the newborn period is often associated with CK-MB release, but in view of the lack of cardiac-specificity of CK-MB in newborn infants, caution is urged in the interpretation of elevated isoenzyme activity in the neonate.
R A Primhak; R Jedeikin; G Ellis; S K Makela; J E Gillan; P R Swyer; R D Rowe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  74     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-26     Completed Date:  1985-08-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  595-600     Citation Subset:  IM    
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MeSH Terms
Asphyxia Neonatorum / complications*
Coronary Disease / diagnosis,  etiology*
Creatine Kinase / blood*
Infant, Newborn
Myocardium / pathology*
Prospective Studies
Reg. No./Substance:
0/Isoenzymes; EC Kinase

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