Document Detail

Myocardial ischaemia in asphyxia neonatorum. Electrocardiographic, enzymatic and histological correlations.
MedLine Citation:
PMID:  4024929     Owner:  NLM     Status:  MEDLINE    
Serial electrocardiograms and creatine kinase (CK) isoenzyme activities were studied prospectively in 20 asphyxiated term newborn infants and 43 normal neonates. By adapting a previously described grading system for ischaemic changes, a degree of electrocardiographic ischaemia was defined which occurred almost solely in asphyxiated infants. Infants with this degree of abnormality had significantly higher mean CK-MB and MM activities than other asphyxiated infants at 0, 8 and 28 hours. Histological changes of peripartum myocardial necrosis were seen in 4 of the 5 infants on whom an autopsy was performed, and either electrocardiogram or CK-MB was abnormal in all four. It is concluded that myocardial injury in the newborn period is often associated with CK-MB release, but in view of the lack of cardiac-specificity of CK-MB in newborn infants, caution is urged in the interpretation of elevated isoenzyme activity in the neonate.
R A Primhak; R Jedeikin; G Ellis; S K Makela; J E Gillan; P R Swyer; R D Rowe
Related Documents :
22070139 - Preterm birth seasonality in greece: an epidemiological study.
22079509 - An algorithm for risk assessment and intervention of mother to child transmission of he...
22091649 - Infant mortality and fertility in three bavarian villages: an analysis of family histor...
24325499 - Training for midwives and obstetricians is required to reduce cases of birth asphyxia.
891569 - Antibody neutralizing material of factor vii during the first weeks of life.
24155449 - Proportional mortality: a study of 152 goats submitted for necropsy from 13 goat herds ...
19365739 - Umbilical cord disruption sequence caused by long cord in two unrelated infants with am...
20660549 - Retinopathy of prematurity in 7 neonatal units in rio de janeiro: screening criteria an...
11808879 - Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. a series of 175 cases.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  74     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-26     Completed Date:  1985-08-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  595-600     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Asphyxia Neonatorum / complications*
Coronary Disease / diagnosis,  etiology*
Creatine Kinase / blood*
Infant, Newborn
Myocardium / pathology*
Prospective Studies
Reg. No./Substance:
0/Isoenzymes; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Acute tubular dysfunction in infants with obstructive uropathy.
Next Document:  Pseudohypoaldosteronism in a female infant and her family: diversity of clinical expression and mode...