| Myocardial ischaemia in asphyxia neonatorum. Electrocardiographic, enzymatic and histological correlations. | |
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MedLine Citation:
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PMID: 4024929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serial electrocardiograms and creatine kinase (CK) isoenzyme activities were studied prospectively in 20 asphyxiated term newborn infants and 43 normal neonates. By adapting a previously described grading system for ischaemic changes, a degree of electrocardiographic ischaemia was defined which occurred almost solely in asphyxiated infants. Infants with this degree of abnormality had significantly higher mean CK-MB and MM activities than other asphyxiated infants at 0, 8 and 28 hours. Histological changes of peripartum myocardial necrosis were seen in 4 of the 5 infants on whom an autopsy was performed, and either electrocardiogram or CK-MB was abnormal in all four. It is concluded that myocardial injury in the newborn period is often associated with CK-MB release, but in view of the lack of cardiac-specificity of CK-MB in newborn infants, caution is urged in the interpretation of elevated isoenzyme activity in the neonate. |
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Authors:
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R A Primhak; R Jedeikin; G Ellis; S K Makela; J E Gillan; P R Swyer; R D Rowe |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta paediatrica Scandinavica Volume: 74 ISSN: 0001-656X ISO Abbreviation: Acta Paediatr Scand Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-08-26 Completed Date: 1985-08-26 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0000211 Medline TA: Acta Paediatr Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 595-600 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Asphyxia Neonatorum
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complications* Coronary Disease / diagnosis, etiology* Creatine Kinase / blood* Electrocardiography Humans Infant, Newborn Isoenzymes Myocardium / pathology* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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