| Myocardial iron overload assessed by magnetic resonance imaging (MRI)T2* in multi-transfused patients with thalassemia and acquired anemias. | |
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MedLine Citation:
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PMID: 21238896 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Cardiac complications secondary to iron overload remain a significant matter in patients with transfusion dependent anemias. PATIENTS AND METHODS: To evaluate cardiac siderosis, Magnetic resonance imaging T2* (MRI T2*) was performed in 3 cohorts of transfusion dependent patients: 99 with thalassemia major (TM), 20 with thalassemia intermedia (TI), and 10 with acquired anemias (AA). Serum ferritin was measured and all patients underwent echocardiographic evaluation. RESULTS: In TM patients cardiac T2* pathologic values (below 20ms) were found in 37 patients. Serum ferritin was negatively associated with age (r=-0.32, p=0.001) and weakly with T2* values (r=-0.19, p=0.057). A positive correlation was found between T2* and LVEF (r=0.27, p=0.006). Out of 37 patients with T2*<20ms, 18 (48%) had serum ferritin values<1000ng/ml. In TI cohort, 3 patients had cardiac T2* pathologic values. In AA cohort, pathologic T2* values were found in 2 patients, who received 234 and 199 PRBC units, respectively, and were both on chelation therapy (in one patient ferritin value was 399ng/ml). T2* values were negatively associated, but not significantly, with the number of PRBC transfused (r=-0.53, p=0.07). CONCLUSION: In our experience, 37% of TM patients had a myocardial iron overload assessed by MRI T2*; this value is higher than in TI patients. Serum ferritin measurement was a poor predictor of myocardial siderosis. In patients with AA, more than 200 PRBC units transfused were required to induce cardiac hemosiderosis, in spite of chelation therapy and, in one patient, of normal ferritin values. |
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Authors:
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Alberto Fragasso; Angela Ciancio; Clara Mannarella; Carlo Gaudiano; Oronzo Scarciolla; Carlo Ottonello; Marco Francone; Michele Nardella; Angelo Peluso; Angela Melpignano; Maria Rosaria Veglio; Giovanni Quarta; Cristiano Turchetti |
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Publication Detail:
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Type: Journal Article Date: 2010-11-24 |
Journal Detail:
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Title: European journal of internal medicine Volume: 22 ISSN: 1879-0828 ISO Abbreviation: Eur. J. Intern. Med. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9003220 Medline TA: Eur J Intern Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 62-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Unità Semplice di Ematologia, Ospedale Madonna delle Grazie, Matera, Italy. |
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