| Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease. | |
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MedLine Citation:
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PMID: 14630822 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac T2* (magnetic resonance imaging relaxation parameter) is abnormally low in approximately 40% of adults with thalassemia major (TM), suggesting myocardial iron deposition, but it is unknown at what age this occurs. To address this question, we measured cardiac T2* and function in 19 young patients (aged 7-26 years) with TM as well as 17 patients receiving long-term transfusions for sickle cell anemia (SCA) matched for age, sex, and liver iron content. Cardiac T2* was normal in all of the SCA patients but was low (high iron) in 8 of 19 TM patients. Abnormal T2* was observed only in the TM patients receiving transfusions for 13 years or longer and was correlated with ferritin but not liver iron levels. Cardiac dysfunction was present in 3 of the 8 patients with low T2*. Cardiac T2* changes have a long latency relative to liver iron accumulation. Total transfusional burden is a significant independent risk factor for low cardiac T2* and may partially account for differences observed between patients with SCA and TM. |
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Authors:
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John C Wood; J Michael Tyszka; Susan Carson; Marvin D Nelson; Thomas D Coates |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2003-11-20 |
Journal Detail:
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Title: Blood Volume: 103 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-02-20 Completed Date: 2004-04-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 1934-6 Citation Subset: AIM; IM |
Affiliation:
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Division of Pediatric Cardiology, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA. jwood@chla.usc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Anemia, Sickle Cell / metabolism* Blood Transfusion Child Female Hemoglobins / biosynthesis Humans Iron / blood*, metabolism* Iron Overload Male Myocardium / metabolism* Sex Factors Thalassemia / metabolism* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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RR00043-43/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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