Document Detail


Myocardial iron loading by magnetic resonance imaging T2* in good prognostic myelodysplastic syndrome patients on long-term blood transfusions.
MedLine Citation:
PMID:  17610536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Magnetic resonance imaging (MRI) was used to quantify myocardial iron loading by T2* in 11 transfusion-dependent good prognostic myelodysplastic syndrome (MDS) patients. Myocardial T2*, left ventricular function and hepatic T2* were measured simultaneously. Patients had been on transfusion therapy for 13-123 months and had serum ferritin levels of 1109-6148 microg/l at the time of study. Five patients had not commenced iron chelation and had been transfused with a median of 63 red cell units and had a median serum ferritin level of 1490 microg/l. Six patients were on iron chelation and had been transfused with a median of 112 red cell units and had a median serum ferritin level of 4809 mug/l. Hepatic iron overload was mild in two, moderate in seven and severe in two patients. The median liver iron concentration was 5.9 mg/g dry weight in chelated patients and 9.5 mg/g in non-chelated patients (P = 0.17; not significant). Myocardial T2* indicated absent iron loading in 10/11 patients (91%; 95% confidence interval 62-98%) and borderline-normal in one patient. Left ventricular function was normal in all patients. No correlation was observed between increasing serum ferritin levels, hepatic iron overload and myocardial T2*. A long latent period relative to hepatic iron loading appears to predate the development of myocardial iron loading in transfusion-dependent MDS patients.
Authors:
Joseph Chacko; Dudley J Pennell; Mark A Tanner; Terry J Hamblin; Beatrix Wonke; Terry Levy; Peter W Thomas; Sally B Killick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-04
Journal Detail:
Title:  British journal of haematology     Volume:  138     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-09     Completed Date:  2007-11-08     Revised Date:  2008-05-02    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  587-93     Citation Subset:  IM    
Affiliation:
Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Blood Transfusion / adverse effects*
Female
Ferritins / blood
Follow-Up Studies
Humans
Iron / metabolism
Iron Chelating Agents / therapeutic use
Iron Overload / diagnosis*,  drug therapy,  etiology,  metabolism
Liver / metabolism
Magnetic Resonance Imaging / methods
Male
Middle Aged
Myelodysplastic Syndromes / metabolism,  therapy*
Myocardium / metabolism*
Prognosis
Prospective Studies
Chemical
Reg. No./Substance:
0/Iron Chelating Agents; 7439-89-6/Iron; 9007-73-2/Ferritins
Comments/Corrections
Comment In:
Br J Haematol. 2008 Feb;140(3):361-2   [PMID:  18067472 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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