| Myocardial iron loading by magnetic resonance imaging T2* in good prognostic myelodysplastic syndrome patients on long-term blood transfusions. | |
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MedLine Citation:
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PMID: 17610536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic resonance imaging (MRI) was used to quantify myocardial iron loading by T2* in 11 transfusion-dependent good prognostic myelodysplastic syndrome (MDS) patients. Myocardial T2*, left ventricular function and hepatic T2* were measured simultaneously. Patients had been on transfusion therapy for 13-123 months and had serum ferritin levels of 1109-6148 microg/l at the time of study. Five patients had not commenced iron chelation and had been transfused with a median of 63 red cell units and had a median serum ferritin level of 1490 microg/l. Six patients were on iron chelation and had been transfused with a median of 112 red cell units and had a median serum ferritin level of 4809 mug/l. Hepatic iron overload was mild in two, moderate in seven and severe in two patients. The median liver iron concentration was 5.9 mg/g dry weight in chelated patients and 9.5 mg/g in non-chelated patients (P = 0.17; not significant). Myocardial T2* indicated absent iron loading in 10/11 patients (91%; 95% confidence interval 62-98%) and borderline-normal in one patient. Left ventricular function was normal in all patients. No correlation was observed between increasing serum ferritin levels, hepatic iron overload and myocardial T2*. A long latent period relative to hepatic iron loading appears to predate the development of myocardial iron loading in transfusion-dependent MDS patients. |
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Authors:
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Joseph Chacko; Dudley J Pennell; Mark A Tanner; Terry J Hamblin; Beatrix Wonke; Terry Levy; Peter W Thomas; Sally B Killick |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-04 |
Journal Detail:
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Title: British journal of haematology Volume: 138 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-09 Completed Date: 2007-11-08 Revised Date: 2008-05-02 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 587-93 Citation Subset: IM |
Affiliation:
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Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Blood Transfusion / adverse effects* Female Ferritins / blood Follow-Up Studies Humans Iron / metabolism Iron Chelating Agents / therapeutic use Iron Overload / diagnosis*, drug therapy, etiology, metabolism Liver / metabolism Magnetic Resonance Imaging / methods Male Middle Aged Myelodysplastic Syndromes / metabolism, therapy* Myocardium / metabolism* Prognosis Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Iron Chelating Agents; 7439-89-6/Iron; 9007-73-2/Ferritins |
| Comments/Corrections | |
Comment In:
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Br J Haematol. 2008 Feb;140(3):361-2
[PMID:
18067472
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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