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Myocardial iron homeostasis in advanced chronic heart failure patients.
MedLine Citation:
PMID:  21899903     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Although, correction of iron deficiency and/or anemia in heart failure (HF) with iron seems promising, little is known about myocardial iron load and homeostasis. Moreover iron supplementation indications are solely based on iron serum markers. The purpose was to assess myocardial iron (M-Iron), ferritin (M-FR), transferrin receptor (M-sTfR) in HF in relation to serum Iron markers. METHODS AND RESULTS: Study group 33 patients, left/right ventricle (LV/RV) (LVEDV 245±84ml; LVESV 189±85ml; LVEF 22±11%; RVD 32±10mm), NTproBNP (5464±4825pg/ml). Iron homeostasis assessment serum: iron, FR, transferrin/saturation (TSAT), sTfR; myocardial: M-Iron (Instrumental Neutron Activation Analysis, μg/g), M-FR, M-sTfR (ELISA - ng/mg protein) in the explanted failing hearts (FH), compared to non-failing hearts (NFH n=11). In FH as compared to NFH, M-Iron was reduced in RV (174±45 vs 233±97, respectively, p=0.07), LV (189±58 vs 265±119, p=0.04), without significant changes in M-FR/M-sTfR. Out of all serum iron markers only sTfR was negatively correlated with M-Iron in either ventricle (RV r=-0.44, p=0.03, LV r=-0.38, p=0.07). With regard to serum iron status, based on TSAT, patients were divided into two subgroups: reduced (TSAT<15%; n=11) and not-reduced serum iron (TSAT≥15%; n=22). Both subgroups had similar grade of LV/RV dysfunction, NT-proBNP levels. M-FR was lower in TSAT<15% than in TSAT≥15% (LV -31±26 vs 46±29; p=0.07) and (RV -24±24 vs 43±29; p=0.02), without differences in M-Iron and M-sTfR. CONCLUSIONS: In HF, M-Iron levels were reduced. Serum iron markers did not reflect M-Iron levels, except for serum sTfR. In reduced serum iron group, decrease in myocardial storage protein M-FR was observed.
Authors:
Przemysław Leszek; Barbara Sochanowicz; Małgorzata Szperl; Piotr Kolsut; Kamil Brzóska; Walerian Piotrowski; Tomasz M Rywik; Bożena Danko; Halina Polkowska-Motrenko; Jacek M Różański; Marcin Kruszewski
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-5
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Institute of Cardiology, ul. Alpejska 42, 04-628 Warszawa, Poland.
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