Document Detail

Myocardial involvement in patients with osteogenesis imperfecta.
MedLine Citation:
PMID:  22398680     Owner:  NLM     Status:  In-Data-Review    
Mitral and aortic valve regurgitation is commonly found in osteogenesis imperfecta (OI) patients, however, little is known about the myocardial involvement in this disorder. An 82-year-old man with OI developed heart failure and was admitted to our hospital. Echocardiogram revealed severe mitral regurgitation without left ventricular (LV) dilatation, but with LV wall thickening. Histological analysis exhibited interstitial fibrosis of the myocardium in addition to myxoid changes of the mitral leaflet. These findings suggest that OI patients may develop LV remodeling together with diastolic dysfunction.
Katsura Soma; Hajime Abe; Norihiko Takeda; Yukako Shintani; Yutaka Takazawa; Toshiya Kojima; Katsuhito Fujiu; Hiroaki Semba; Hiroshi Yamashita; Yasunobu Hirata; Masashi Fukayama; Ryozo Nagai
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International heart journal     Volume:  53     ISSN:  1349-3299     ISO Abbreviation:  Int Heart J     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  75-7     Citation Subset:  IM    
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.
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