| Myocardial intensity changes associated with flow stimulation in blood oxygenation sensitive magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 8795024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Functional magnetic resonance imaging exploits deoxygenated blood as an endogenous source for contrast in assessing local changes in tissue perfusion. Intrinsic changes in myocardial signal intensity were measured during dipyridamole induced coronary vasodilatation with T2*-weighted echo planar MRI in healthy volunteers. Concurrently, changes in flow velocity in the left anterior descending coronary artery were measured using a time-of-flight method. Dipyridamole infusion produced 14 +/- 6% increase in myocardial signal intensity (n = 7). Temporal profile of the myocardial signal intensity changes correlated well with the augmentation of coronary flow velocity. The data are consistent with the concept that changes in myocardial deoxyhemoglobin content due to altered flow result in changes in magnetic susceptibility that can be detected on T2*-weighted MR images. |
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Authors:
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P Niemi; B P Poncelet; K K Kwong; R M Weisskoff; B R Rosen; T J Brady; H L Kantor |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 36 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-11-19 Completed Date: 1996-11-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 78-82 Citation Subset: IM |
Affiliation:
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Department of Radiology, Massachusetts General Hospital, Charlestown, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity / drug effects Blood Pressure / drug effects Contrast Media Coronary Circulation* / drug effects Coronary Vessels / drug effects Dipyridamole / pharmacology Echo-Planar Imaging / methods* Heart / anatomy & histology* Heart Rate / drug effects Heart Septum / metabolism, pathology Hemoglobins / metabolism Humans Hyperemia / metabolism Image Enhancement / methods* Myocardium / metabolism Oxygen / blood* Oxygen Consumption Vasodilator Agents / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL 39810/HL/NHLBI NIH HHS; P01 #48729//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Hemoglobins; 0/Vasodilator Agents; 58-32-2/Dipyridamole; 7782-44-7/Oxygen; 9008-02-0/deoxyhemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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