Document Detail


Myocardial inflammation and non-ischaemic heart failure: is there a role for C-reactive protein?
MedLine Citation:
PMID:  19343415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Whereas C-reactive protein (CRP) is acknowledged as a cardiovascular risk marker, there is ongoing discussion about its role as a risk factor. Previous studies focused on the effects of CRP on ischaemic heart failure and atherosclerosis. In this study we investigated distribution of CRP, the Terminal Complement Complex (C5b-9) and macrophages (CD68) in the myocardium of patients suffering from non-ischaemic heart failure and their implication on clinical parameters. Endomyocardial biopsies were taken from 66 patients suffering from dilated cardiomyopathy (DCM). Biopsies were analysed by immunohistochemical and immunofluorescent staining for CRP, C5b-9 and CD68. Viral DNA/RNA for adenovirus, enterovirus, parvovirus B19 and human herpes virus 6 was detected by PCR and Southern blot analysis. Myocardial biopsy findings were correlated with plasma level of hsCRP and NT-proBNP as well as echocardiography, exercise test and NYHA class. In 18 (27%) patients, a positive staining for CRP and in 57 (86%) patients a positive staining for C5b-9 was detected. All patients showed myocardial infiltration with macrophages with an average of 39 cells/mm(2). CRP, C5b-9 and CD68 co-localised within the myocardium. No correlation was observed for inflammatory proteins and plasma level of hsCRP, NT-proBNP and clinical parameters. CRP is frequently present in the myocardium of patients suffering from DCM and co-localises with C5b-9 and macrophages. CRP may contribute to myocardial damage in DCM via activation of the complement system and chemotaxis of macrophages.
Authors:
Oliver Zimmermann; Magdalena Bienek-Ziolkowski; Bettina Wolf; Martin Vetter; Regine Baur; Volker Mailänder; Vinzenz Hombach; Jan Torzewski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-03
Journal Detail:
Title:  Basic research in cardiology     Volume:  104     ISSN:  1435-1803     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-07     Completed Date:  2009-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  591-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine II-Cardiology, University of Ulm, Ulm, Germany. oliver.zimmermann@uniklinik-ulm.de
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MeSH Terms
Descriptor/Qualifier:
Adenoviridae / genetics
Adult
Aged
Antigens, CD / analysis
Antigens, Differentiation, Myelomonocytic / analysis
Biopsy
C-Reactive Protein / analysis*
Cardiomyopathy, Dilated / immunology*,  ultrasonography,  virology
Complement Membrane Attack Complex / analysis
DNA, Viral / isolation & purification
Enterovirus / genetics
Exercise Test
Female
Heart Failure / immunology*,  ultrasonography,  virology
Herpesvirus 6, Human / genetics
Humans
Macrophages / immunology
Male
Middle Aged
Myocarditis / immunology*,  ultrasonography,  virology
Myocardium / immunology*,  pathology
Natriuretic Peptide, Brain / analysis,  blood
Parvovirus B19, Human / genetics
Peptide Fragments / analysis,  blood
RNA, Viral / isolation & purification
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 0/Complement Membrane Attack Complex; 0/DNA, Viral; 0/Peptide Fragments; 0/RNA, Viral; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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