Document Detail

Myocardial infarction with normal coronary arteries: a conundrum with multiple aetiologies and variable prognosis: an update.
MedLine Citation:
PMID:  17391108     Owner:  NLM     Status:  MEDLINE    
The existence of myocardial infarction despite angiographically normal coronary arteries was recognized more than 30 years ago. Since then, various series of such patients have been described, but the aetiology and pathogenesis of the condition are still a source of debate. Evidence exists for a role of coronary vasospasm, thrombosis, embolization and inflammation, per se or combined, in determining the occurrence of myocardial infarction in the presence of angiographically normal coronary arteries. Endothelial dysfunction, possibly superimposed to nonangiographically evident atherosclerosis, may be an underlying common feature predisposing to the acute event. Additionally, myocarditis may explain some of these occurrences. Myocardial infarction with normal coronary arteries is therefore likely the result of multiple pathogenetic mechanisms. Although most reports emphasize the good prognosis of this condition, in general much better than myocardial infarction with coronary artery disease, prognosis is likely variable according to the underlying mechanism. This review summarizes current knowledge on this condition and examines areas of recent progress.
I Kardasz; R De Caterina
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of internal medicine     Volume:  261     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-29     Completed Date:  2007-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  330-48     Citation Subset:  IM    
Institute of Cardiology and Center of Excellence on Aging, G. d'Annunzio University - Chieti, Chieti, and CNR Institute of Clinical Physiology, Pisa, Italy.
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MeSH Terms
Coronary Angiography*
Coronary Disease / complications*,  diagnosis
Diagnosis, Differential
Middle Aged
Myocardial Infarction / etiology*,  physiopathology
Myocarditis / complications,  diagnosis
Thrombophilia / complications,  diagnosis
Ventricular Dysfunction, Left / complications,  diagnosis

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