| Myocardial infarction and venous thrombosis in a 42-year old woman with heterozygous methylenetetrahydrofolate reductase (MTHRF) gene mutation, hyperhomocysteinemia, and protein C deficiency. | |
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MedLine Citation:
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PMID: 17360059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Hyperhomocysteinemia and protein C deficiency have synergistic effect on the onset of thrombotic disease. METHODS: We report a 42-year old woman with myocardial infarction and venous thrombosis in whom recognition of heterozygous MTHRF gene mutation, hyperhomocysteinemia, and protein C deficiency. RESULTS: The patient was treated successfully with coronary artery bypass graft surgery and systemic anticoagulation. CONCLUSIONS: Our report emphasize that a combined hyperhomocysteinemia, and protein C deficiency may be a high risk factor for arterial and venous thromboembolic events in young adults. These patients might be candidates for indefinite anticoagulation. |
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Authors:
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Omer Cakir; Orhan Ayyildiz; Mustafa Goz; Dede Sit; Nesimi Eren |
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Publication Detail:
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Type: Case Reports; Letter Date: 2007-03-13 |
Journal Detail:
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Title: International journal of cardiology Volume: 117 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-06 Completed Date: 2007-07-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: e98-100 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Heterozygote Humans Hyperhomocysteinemia / complications* Methylenetetrahydrofolate Reductase (NADPH2) / genetics* Mutation* Myocardial Infarction / etiology* Protein C Deficiency / complications* Venous Thrombosis / etiology* |
| Chemical | |
Reg. No./Substance:
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EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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