Document Detail

Myocardial infarction and venous thrombosis in a 42-year old woman with heterozygous methylenetetrahydrofolate reductase (MTHRF) gene mutation, hyperhomocysteinemia, and protein C deficiency.
MedLine Citation:
PMID:  17360059     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Hyperhomocysteinemia and protein C deficiency have synergistic effect on the onset of thrombotic disease. METHODS: We report a 42-year old woman with myocardial infarction and venous thrombosis in whom recognition of heterozygous MTHRF gene mutation, hyperhomocysteinemia, and protein C deficiency. RESULTS: The patient was treated successfully with coronary artery bypass graft surgery and systemic anticoagulation. CONCLUSIONS: Our report emphasize that a combined hyperhomocysteinemia, and protein C deficiency may be a high risk factor for arterial and venous thromboembolic events in young adults. These patients might be candidates for indefinite anticoagulation.
Omer Cakir; Orhan Ayyildiz; Mustafa Goz; Dede Sit; Nesimi Eren
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Publication Detail:
Type:  Case Reports; Letter     Date:  2007-03-13
Journal Detail:
Title:  International journal of cardiology     Volume:  117     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-06     Completed Date:  2007-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e98-100     Citation Subset:  IM    
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MeSH Terms
Hyperhomocysteinemia / complications*
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Myocardial Infarction / etiology*
Protein C Deficiency / complications*
Venous Thrombosis / etiology*
Reg. No./Substance:
EC Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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