| Myocardial infarction and intramyocardial injection models in swine. | |
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MedLine Citation:
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PMID: 22790084 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Sustainable and reproducible large animal models that closely replicate the clinical sequelae of myocardial infarction (MI) are important for the translation of basic science research into bedside medicine. Swine are well accepted by the scientific community for cardiovascular research, and they represent an established animal model for preclinical trials for US Food and Drug Administration (FDA) approval of novel therapies. Here we present a protocol for using porcine models of MI created with a closed-chest coronary artery occlusion-reperfusion technique. This creates a model of MI encompassing the anteroapical, lateral and septal walls of the left ventricle. This model infarction can be easily adapted to suit individual study design and enables the investigation of a variety of possible interventions. This model is therefore a useful tool for translational research into the pathophysiology of ventricular remodeling and is an ideal testing platform for novel biological approaches targeting regenerative medicine. This model can be created in approximately 8-10 h. |
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Authors:
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Frederic C McCall; Kartik S Telukuntla; Vasileios Karantalis; Viky Y Suncion; Alan W Heldman; Muzammil Mushtaq; Adam R Williams; Joshua M Hare |
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Publication Detail:
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Type: Journal Article Date: 2012-07-12 |
Journal Detail:
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Title: Nature protocols Volume: 7 ISSN: 1750-2799 ISO Abbreviation: Nat Protoc Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-07-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101284307 Medline TA: Nat Protoc Country: England |
Other Details:
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Languages: eng Pagination: 1479-96 Citation Subset: IM |
Affiliation:
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Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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