Document Detail

Myocardial infarction in spontaneously hypertensive rats with superimposed adrenal-regeneration hypertension.
MedLine Citation:
PMID:  508586     Owner:  NLM     Status:  MEDLINE    
The elevated blood pressure of spontaneously hypertensive rats (SHR) was further exacerbated by subjecting these animals to surgically induced adrenal-regeneration hypertension (ARH). When chronic abnormally high blood pressure had been in effect for 12 weeks, the animals were subjected to an acute and massive myocardial infarction with isoprenaline. Hypertensive but intact SHR survived better than ARH-treated animals. Circulating enzyme (CPK, SGOT, SGPT and LDH), lipid and glucose levels and BUN manifested much greater excursions commensurate with more extensive myocardial infarction in ARH-treated than in intact SHR. ARH-treated SHR displayed a high incidence of atrial and ventricular thrombi associated with frequent left ventricular aneurysm formation. It is suggested that the more extensive myocardial connective tissue and ground-substance degeneration in ARH-treated SHR is due to the impoverished steroidogenic capacity of their regenerated adrenal glands.
B C Wexler
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of experimental pathology     Volume:  60     ISSN:  0007-1021     ISO Abbreviation:  Br J Exp Pathol     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1980-02-28     Completed Date:  1980-02-28     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  0372543     Medline TA:  Br J Exp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  366-81     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / physiopathology
Blood Urea Nitrogen
Body Weight
Corticosterone / blood
Enzymes / blood
Hypertension / blood,  complications*,  pathology
Lipids / blood
Myocardial Infarction / chemically induced,  complications*,  pathology
Myocardium / pathology
Organ Size
Reg. No./Substance:
0/Enzymes; 0/Lipids; 50-22-6/Corticosterone; 7683-59-2/Isoproterenol

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