| Myocardial infarction in sickle cell disease. | |
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MedLine Citation:
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PMID: 8764524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gross and microscopic findings consistent with acute (three patients) and healed (four patients) myocardial infarction were found in seven (9.7%) of 72 consecutive hearts from patients with sickle cell disease studied after autopsy between 1950 and 1982. Gross obstructive and atherosclerotic lesions were absent in all seven patients, while microthrombi were present in the arterioles of infarcted tissue in two patients. Pathophysiological mechanisms responsible for the infarction are unclear, but anemia, platelet thrombi, coronary vasospasm, and abnormal rheology related to sickle cells may all be important. Chest pain occurred clinically in six of the seven patients and ECG findings typical of infarction were found in two patients. One patient died suddenly. These findings suggest that ischemic heart disease may be present in a significant number of patients with sickle cell disease and should be considered in all patients who complain of chest pain, whether or not the patient is in crisis. |
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Authors:
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C R Martin; C S Johnson; C Cobb; D Tatter; L J Haywood |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the National Medical Association Volume: 88 ISSN: 0027-9684 ISO Abbreviation: J Natl Med Assoc Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-09-20 Completed Date: 1996-09-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503090 Medline TA: J Natl Med Assoc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 428-32 Citation Subset: IM |
Affiliation:
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Department of Medicine, LAC+USC Medical Center 90033, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anemia, Sickle Cell / complications*, pathology Autopsy Female Humans Male Middle Aged Myocardial Infarction / complications*, epidemiology, pathology Prevalence Risk Factors |
| Comments/Corrections | |
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