Document Detail

Myocardial infarction in sickle cell disease.
MedLine Citation:
PMID:  8764524     Owner:  NLM     Status:  MEDLINE    
Gross and microscopic findings consistent with acute (three patients) and healed (four patients) myocardial infarction were found in seven (9.7%) of 72 consecutive hearts from patients with sickle cell disease studied after autopsy between 1950 and 1982. Gross obstructive and atherosclerotic lesions were absent in all seven patients, while microthrombi were present in the arterioles of infarcted tissue in two patients. Pathophysiological mechanisms responsible for the infarction are unclear, but anemia, platelet thrombi, coronary vasospasm, and abnormal rheology related to sickle cells may all be important. Chest pain occurred clinically in six of the seven patients and ECG findings typical of infarction were found in two patients. One patient died suddenly. These findings suggest that ischemic heart disease may be present in a significant number of patients with sickle cell disease and should be considered in all patients who complain of chest pain, whether or not the patient is in crisis.
C R Martin; C S Johnson; C Cobb; D Tatter; L J Haywood
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the National Medical Association     Volume:  88     ISSN:  0027-9684     ISO Abbreviation:  J Natl Med Assoc     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-09-20     Completed Date:  1996-09-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503090     Medline TA:  J Natl Med Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  428-32     Citation Subset:  IM    
Department of Medicine, LAC+USC Medical Center 90033, USA.
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MeSH Terms
Anemia, Sickle Cell / complications*,  pathology
Middle Aged
Myocardial Infarction / complications*,  epidemiology,  pathology
Risk Factors

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