Document Detail

Myocardial infarction as an uncommon clinical manifestation of intravascular large cell lymphoma.
MedLine Citation:
PMID:  16261789     Owner:  NLM     Status:  MEDLINE    
Intravascular large cell lymphoma (IVL) is a very rare variant of non-Hodgkin's lymphoma presenting with puzzling clinical manifestations. There is a predilection for the central nervous system, but the tumour often affects also skin, lung, and kidneys while lymphadenopathy and hepatosplenomegaly are usually absent. Myocardial infarction due to IVL has not been reported so far. We here report on a 56-year-old patient who was admitted to our hospital with fever and clinical signs of erysipelas. He had a 6-month history of "collagen vasculitic disease" treated with prednisolone and azathioprine. He received antibiotic treatment, but after transient improvement fever recurred with generalized seizures and myocardial infarction, which required transfer to the intensive care unit where the patient died with signs of an acute cardiogenic shock. Autopsy revealed a generalized high-grade B cell lymphoma of IVL type affecting and obstructing small vessels of a variety of tissues including heart, brain and lungs. The tumorous obliteration of small intramyocardial vessels had led to an acute ischaemia with infarction and subsequent signs of myocardial insufficiency. To the best of the authors' knowledge myocardial infarction as a leading symptom of IVL has not been described.
Alexander Bauer; Boris Perras; Sven Sufke; Hans-Peter Horny; Burkhard Kreft
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta cardiologica     Volume:  60     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-11-02     Completed Date:  2006-01-20     Revised Date:  2009-06-11    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  551-5     Citation Subset:  IM    
Dept of Internal Medicine I, University of Lübeck, Germany.
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MeSH Terms
Blood Vessels / pathology
Brain / blood supply
Coronary Vessels / pathology
Fatal Outcome
Lung / blood supply
Lymphoma, Large B-Cell, Diffuse / complications*,  pathology
Middle Aged
Myocardial Infarction / etiology*,  pathology
Shock, Cardiogenic / etiology*,  pathology
Vascular Neoplasms / complications*,  pathology

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