Document Detail

Myocardial infarct size: clinicopathologic agreement and discordance.
MedLine Citation:
PMID:  72721     Owner:  NLM     Status:  MEDLINE    
An accurate postmortem method of planimetrically estimating the extent of myocardial infarction was employed in 16 cases. Delineation of necrotic myocardium was enhanced by a macroscopic staining technique, which utilizes a tetrazolium dye. Comparison of infarct size with peak serum creatine phosphokinase levels showed a general correlation between the two that was not statistically significant. Two markedly disparate cases serve to emphasize the need for clinical awareness of the temporal relationship between myocardial infarction and creatinine phosphokinase analysis as well as the possibility of other anatomic sources of elevation of serum enzyme levels. Comparison of infarct sizes in cardiogenic shock and nonshock patients confirms the existence of a significant relationship between a larger myocardial infarct and shock. However, the data from several patients in the group again emphasize the possibility of maintaining a reasonable blood pressure in the face of a massive myocardial infarction or, more importantly, of manifesting "cardiogenic" shock when only a small amount of left ventricular damage has been sustained. The latter possibility may be related to other anatomic events, e.g., bowel infarction, hemorrhage, or possibly right ventricular ischemia, infarction, or dysfunction.
P J Boor; E S Reynolds
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human pathology     Volume:  8     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1978-01-27     Completed Date:  1978-01-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  685-95     Citation Subset:  IM    
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MeSH Terms
Creatine Kinase / blood
Myocardial Infarction / blood,  pathology*
Myocardium / pathology*
Shock, Cardiogenic / pathology
Staining and Labeling
Statistics as Topic
Reg. No./Substance:
EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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