Document Detail

Myocardial infarct size. Measurements and predictions.
MedLine Citation:
PMID:  6445181     Owner:  NLM     Status:  MEDLINE    
Because patient prognosis is related in part to infarct size, therapies that could limit infarct size should be beneficial. The development of such therapies has been hampered by the lack of proven techniques to measure infarct size or to assess the effect of therapy in living patients. In addition, the evolution of ischemic cell death in human infarcts is not understood, and therefore the amount of ischemic myocardium that might be salvageable at various times after the onset of myocardial infarction is unknown. Experimental studies have contributed to our understanding of the evolution of acute myocardial infarcts. However, there is a continuing need for experimental and human anatomical studies to validate indirect in vivo techniques of estimating infarct size. In addition, reliable experimental models in which potential therapies can be tested are needed. In dogs, infarct size is predetermined in part by the amount of myocardium at risk and the amount of collateral flow in this risk region. Measuring these parameters should provide a framework within which the effects of therapy on infarct size can be assessed.
K A Reimer
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  104     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-06-27     Completed Date:  1980-06-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  225-30     Citation Subset:  AIM; IM    
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MeSH Terms
Arrhythmias, Cardiac / etiology
Cardiomegaly / etiology
Cell Survival
Collateral Circulation
Coronary Vessels
Creatine Kinase / blood
Dye Dilution Technique
Histological Techniques
Myocardial Infarction / complications,  diagnosis,  pathology*,  therapy
Myocardium / metabolism
Myoglobin / blood
Oxygen Consumption
Shock, Cardiogenic / etiology
Time Factors
Reg. No./Substance:
0/Isoenzymes; 0/Myoglobin; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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