Document Detail


Myocardial indium-111-antimyosin uptake in essential hypertension.
MedLine Citation:
PMID:  12802472     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Evaluation of myocardial uptake of (111)In-anti-myosin antibodies in patients with essential hypertension for the verification of our hypothesis that it may increase in stage 1 in the left ventricle as a result of myocardial damage. PATIENTS, METHODS: Twelve men (mean age: 59+/-2.4 years) suffering from angina like symptoms and essential hypertension in clinical stage 1 according to the JNC-VI criteria were included into the study. These patients showed normal perfusion as revealed by thallium-201 myocardial study and coronary angiography. Left ventricular mass index was determined in echocardiography. Planar antimyosin images were obtained 48 h after the intravenous injection of the tracer. Heart to lung ratios were calculated as a parameter of myocardial tracer uptake using appropriate region of interests; values>1.52 were considered as abnormal. RESULTS: We observed increased anti-myosin uptake (mean: 1.71+/-0.12) consistent with myocardial damage in 11 of 12 patients. Nine of 12 patients had a left ventricular hypertrophy with left ventricular mass index values (mean: 131 g/m(2)+/-9.48) above 115 g/m(2). Heart to lung ratio was correlated significantly to left ventricular mass index (r = 0.902, p<0.001) and duration of hypertension (r = 0.948, p<0.001). CONCLUSION: Our results suggest that (111)In-antimyosin imaging may indicate myocyte damage in early phases of hypertensive heart disease.
Authors:
M Unlü; N H Temiz; A Cengel
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuklearmedizin. Nuclear medicine     Volume:  42     ISSN:  0029-5566     ISO Abbreviation:  Nuklearmedizin     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-12     Completed Date:  2003-08-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7609387     Medline TA:  Nuklearmedizin     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  99-103     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Gazi University School of Medicine, Ankara, Turkey. mustafaunlutr@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Antibodies, Monoclonal / diagnostic use,  pharmacokinetics*
Antihypertensive Agents / therapeutic use
Blood Pressure
Humans
Hypertension / drug therapy,  physiopathology,  radionuclide imaging*
Indapamide / therapeutic use
Indium Radioisotopes / diagnostic use,  pharmacokinetics*
Male
Middle Aged
Myosins / diagnostic use,  pharmacokinetics
Organometallic Compounds / diagnostic use,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antihypertensive Agents; 0/Indium Radioisotopes; 0/Organometallic Compounds; 138660-99-8/imciromab pentetate; 26807-65-8/Indapamide; EC 3.6.4.1/Myosins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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