Document Detail


Myocardial imaging with dipyridamole: comparison of the sensitivity and specificity of 201Tl versus MUGA.
MedLine Citation:
PMID:  6460627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myocardial imaging was performed at rest and after dipyridamole infusion using 201Tl and 99Tcm - gated blood pool studies (MUGA). Of 38 patients studied, 21 had coronary artery disease (CAD) and 17 were normal. With 201Tl imaging, 19 of 21 patients with CAD (sensitivity 88%) showed perfusion defects during dipyridamole. Of 17 normals 6 (specificity 65%) showed clear perfusion defects during dipyridamole. With MUGA, 2 of 15 patients with CAD (sensitivity 13%) developed abnormal wall motion during dipyridamole; both patients developed ST depression greater than 1 mm. Of 10 normals none developed abnormal wall motion. Twenty six of 38 patients developed angina during dipyridamole, which was reversed by aminophylline in 24 of 26. We suggest that dipyridamole infusion is effective for 201Tl-perfusion imaging, and easily performed, but is not suitable for MUGA studies where ischaemia is the required endpoint.
Authors:
D Harris; D Taylor; B Condon; D Ackery; N Conway
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  7     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1982  
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aminophylline / therapeutic use
Coronary Circulation
Coronary Disease / radionuclide imaging
Dipyridamole / diagnostic use*
Heart / radionuclide imaging*
Humans
Physical Exertion
Radioisotopes / diagnostic use*
Serum Albumin / diagnostic use
Technetium / diagnostic use
Technetium Tc 99m Aggregated Albumin
Thallium / diagnostic use*
Chemical
Reg. No./Substance:
0/Radioisotopes; 0/Serum Albumin; 0/Technetium Tc 99m Aggregated Albumin; 317-34-0/Aminophylline; 58-32-2/Dipyridamole; 7440-26-8/Technetium; 7440-28-0/Thallium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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