Document Detail


Myocardial hypothermia: a potential therapeutic technique for acute regional myocardial ischemia.
MedLine Citation:
PMID:  10210504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The importance of temperature in the development of necrosis after myocardial ischemia in the beating heart is becoming apparent. Recent studies have shown that the proportion of the ischemic risk zone that becomes necrotic is directly correlated with temperature. This fact suggests the potential therapeutic benefits of reducing myocardial temperature after coronary artery occlusion. We have shown in a number of experimental protocols in the rabbit model of myocardial infarction that topical regional hypothermia reduces infarct size even when instituted after coronary artery occlusion. The reduction in myocardial temperature required to obtain this benefit is modest ( 30 degrees C to 34 degrees C). Topical regional hypothermia allows targeted cooling of a zone of the heart. Myocardial cooling can also be achieved by perfusing the pericardial sac with a chilled fluid by using a closed-circuit catheter system that does not cause cardiac tamponade. This technique also protects myocardium during ischemia. Myocardial hypothermia might be a useful technique to limit ischemic damage during infarction or as adjunctive therapy during minimally invasive cardiac surgery.
Authors:
S L Hale; R A Kloner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  10     ISSN:  1045-3873     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-08     Completed Date:  1999-06-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  405-13     Citation Subset:  IM    
Affiliation:
The Heart Institute of Good Samaritan Hospital, Los Angeles, California 90017, USA. sharon.hale@ibm.net
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Body Temperature
Cardioplegic Solutions / administration & dosage
Disease Models, Animal
Heart / physiopathology*
Heart Arrest, Induced / methods
Hypothermia, Induced / methods*
Myocardial Ischemia / therapy*
Perfusion / methods
Pericardium
Chemical
Reg. No./Substance:
0/Cardioplegic Solutions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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