Document Detail

Myocardial hypertrophy and the maturation of fatty acid oxidation in the newborn human heart.
MedLine Citation:
PMID:  18614968     Owner:  NLM     Status:  MEDLINE    
After birth dramatic decreases in cardiac malonyl CoA levels result in the rapid maturation of fatty acid oxidation. We have previously demonstrated that the decrease in malonyl CoA is due to increased activity of malonyl CoA decarboxylase (MCD), and decreased activity of acetyl CoA carboxylase (ACC), enzymes which degrade and synthesize malonyl CoA, respectively. Decreased ACC activity corresponds to an increase in the activity of 5'-AMP activated protein kinase (AMPK), which phosphorylates and inhibits ACC. These alterations are delayed by myocardial hypertrophy. As rates of fatty acid oxidation can influence the ability of the heart to withstand an ischemic insult, we examined the expression of MCD, ACC, and AMPK in the newborn human heart. Ventricular biopsies were obtained from infants undergoing cardiac surgery. Immunoblot analysis showed a positive correlation between MCD expression and age. In contrast, a negative correlation in both ACC and AMPK expression and age was observed. All ventricular samples displayed some degree of hypertrophy, however, no differences in enzyme expression were found between moderate and severe hypertrophy. This indicates that increased expression of MCD, and the decreased expression of ACC and AMPK are important regulators of the maturation of fatty acid oxidation in the newborn human heart.
Michael A Yatscoff; Jagdip S Jaswal; Meghan R Grant; Rachel Greenwood; Trish Lukat; Donna L Beker; Ivan M Rebeyka; Gary D Lopaschuk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  64     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-02     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  643-7     Citation Subset:  IM    
Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2S2, Canada.
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MeSH Terms
AMP-Activated Protein Kinases / metabolism*
Acetyl-CoA Carboxylase / metabolism*
Aging / physiology
Carboxy-Lyases / metabolism*
Fatty Acids / chemistry,  metabolism*
Heart Ventricles / enzymology,  pathology
Hypertrophy* / enzymology,  pathology
Infant, Newborn
Malonyl Coenzyme A / metabolism
Myocardium* / enzymology,  pathology
Reg. No./Substance:
0/Fatty Acids; 524-14-1/Malonyl Coenzyme A; EC Protein Kinases; EC 4.1.1.-/Carboxy-Lyases; EC decarboxylase; EC Carboxylase

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