Document Detail

Myocardial histological changes in dilated cardiomyopathy during a long-term left ventricular assist device support.
MedLine Citation:
PMID:  9403314     Owner:  NLM     Status:  MEDLINE    
As the myocardium in patients with dilated cardiomyopathy (DCM) is deteriorating progressively, resulting in a decrease in left ventricular function, patients with end-stage DCM may require implantation of a left ventricular assist device (LVAD) unless they undergo heart transplantation. Although LVAD has been reported to provide excellent hemodynamic support, no data are currently available about the effects of long-term LVAD support on the myocardium in patients with DCM. We describe two patients with end-stage DCM who underwent LVAD implantation and were supported with LVAD for 524 and 245 days, respectively. Serial myocardial biopsies showed increases in myocardial cell diameter and intercellular fibrosis, despite excellent hemodynamic support by LVAD. These data suggest that the myocardium in patients with end-stage DCM deteriorates progressively, even if the pre-load of the left ventricle is reduced by LVAD.
S Taketani; Y Sawa; N Fukushima; T Masai; N Kawaguchi; S Onishi; H Matsuda
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Heart and vessels     Volume:  12     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  1997  
Date Detail:
Created Date:  1998-01-08     Completed Date:  1998-01-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  98-100     Citation Subset:  IM    
First Department of Surgery, Osaka University Medical School, Japan.
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MeSH Terms
Cardiomyopathy, Dilated / pathology*,  therapy*
Disease Progression
Heart-Assist Devices*
Middle Aged
Myocardium / pathology*
Time Factors

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