| Myocardial histological changes in dilated cardiomyopathy during a long-term left ventricular assist device support. | |
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MedLine Citation:
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PMID: 9403314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As the myocardium in patients with dilated cardiomyopathy (DCM) is deteriorating progressively, resulting in a decrease in left ventricular function, patients with end-stage DCM may require implantation of a left ventricular assist device (LVAD) unless they undergo heart transplantation. Although LVAD has been reported to provide excellent hemodynamic support, no data are currently available about the effects of long-term LVAD support on the myocardium in patients with DCM. We describe two patients with end-stage DCM who underwent LVAD implantation and were supported with LVAD for 524 and 245 days, respectively. Serial myocardial biopsies showed increases in myocardial cell diameter and intercellular fibrosis, despite excellent hemodynamic support by LVAD. These data suggest that the myocardium in patients with end-stage DCM deteriorates progressively, even if the pre-load of the left ventricle is reduced by LVAD. |
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Authors:
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S Taketani; Y Sawa; N Fukushima; T Masai; N Kawaguchi; S Onishi; H Matsuda |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Heart and vessels Volume: 12 ISSN: 0910-8327 ISO Abbreviation: Heart Vessels Publication Date: 1997 |
Date Detail:
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Created Date: 1998-01-08 Completed Date: 1998-01-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: JAPAN |
Other Details:
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Languages: eng Pagination: 98-100 Citation Subset: IM |
Affiliation:
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First Department of Surgery, Osaka University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Cardiomyopathy, Dilated / pathology*, therapy* Disease Progression Fibrosis Heart-Assist Devices* Humans Male Middle Aged Myocardium / pathology* Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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