| Myocardial high-energy phosphate metabolism is altered after treatment with anthracycline in childhood. | |
| | |
MedLine Citation:
|
PMID: 11117394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: We aimed to investigate whether changes in high-energy phosphate metabolism after treatment of children and young adults with anthracycline can be demonstrated non-invasively by 31P magnetic resonance spectroscopy. BACKGROUND: Abnormal myocardial energy metabolism has been suggested as a mechanism for anthracycline-induced cardiotoxicity. Deterioration in such has been shown in animal studies by resonance spectroscopy. METHODS: We studied 62 patients, with a mean age of 13.5+/-5 years, 3.7+/-4.3 years after a cumulative anthracycline dose of 270+/-137 mg/m2. Normal echocardiographic findings had been elicited in 54 patients. The control group consisted of 28 healthy subjects aged 20+/-7 years. Resonance spectrums of the anterior left ventricular myocardium were obtained at 1.5 Tesla using an image-selected in vivo spectroscopy localization technique. RESULTS: The ratio of phosphocreatine to adenosine triphosphate after blood correction was 1.09+/-0.43 for the patients, and 1.36+/-0.36 (mean+/-SD) for controls (p=0.005), with a significantly reduced mean ratio even in the subgroup of patients with normal echocardiographic results (1.11+/-0.44 versus 1.36+/-0.36, p=0.01). The ratio did not correlate with the cumulative dose of anthracycline. The ratio of phosphodiester to adenosine triphosphate was similar in patients and controls (0.90+/-0.56 versus 0.88+/-0.62). CONCLUSIONS: In patients treated with anthracyclines in childhood, myocardial high-energy phosphate metabolism may be impaired even in the absence of cardiomyopathy. Our data support the concept that anthracycline-induced cardiotoxicity is not clearly dose dependent. |
| | |
Authors:
|
A B Eidenschink; G Schröter; S Müller-Weihrich; H Stern |
Related Documents
:
|
19327434 - Usefulness of two-dimensional speckle tracking echocardiography for assessment of tako-... 14618214 - Echocardiographic monitoring of left ventricular regional motion during hyperventilatio... 19438694 - Assessment of left ventricular systolic synchronization in patients with chronic kidney... 18393114 - Assessment of left and right ventricular diastolic function in patients with systemic s... 22222234 - Synovial fluid omentin-1 levels are inversely correlated with radiographic severity of ... 10233264 - The autologous serum skin test: a screening test for autoantibodies in chronic idiopath... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cardiology in the young Volume: 10 ISSN: 1047-9511 ISO Abbreviation: Cardiol Young Publication Date: 2000 Nov |
Date Detail:
|
Created Date: 2000-12-14 Completed Date: 2000-12-28 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9200019 Medline TA: Cardiol Young Country: England |
Other Details:
|
Languages: eng Pagination: 610-7 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Technical University of Munich, Germany. Andrea@Eidenschinks.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Triphosphate
/
metabolism Adolescent Adult Anthracyclines / adverse effects*, therapeutic use Child Child, Preschool Energy Metabolism / drug effects* Female Humans Magnetic Resonance Spectroscopy Male Myocardium / metabolism* Neoplasms / drug therapy Phosphates / metabolism* Phosphocreatine / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Anthracyclines; 0/Phosphates; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transthoracic three-dimensional echocardiography for the assessment of straddling tricuspid or mitra...
Next Document: Familial absent pulmonary valve syndrome without deletions of chromosome 22q11.