| Myocardial hibernation. Clinical and pathological perspectives. | |
| | |
MedLine Citation:
|
PMID: 12867878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Myocardial hibernation refers to a state of persistent regional contractile ventricular dysfunction, in patients with coronary artery disease that is reversible with revascularization. Identification of hibernating myocardial segments is critical for selecting patients who are most likely to benefit from revascularization procedures. Positron emission tomography, thallium scintigraphy, dobutamine stress echocardiography, myocardial contrast echocardiography and magnetic resonance imaging have been extensively used for detection of viable dysfunctional myocardial segments. Although chronic hypoperfusion and repetitive episodes of brief ischemia may play a role in mediating the changes associated with myocardial hibernation the exact pathogenetic mechanisms are not well understood. The structural alterations found in hibernating myocardial segments involve both the cardio-myocytes and the cardiac interstitium. Depletion of contractile elements, loss of myofilaments, disorganization of myocyte cytoskeletal proteins and alterations in adrenergic receptor density have been reported in segments with reversible systolic dysfunction and may cause segmental hypocontractility. In addition, activation of the inflammatory cascade is noted, leading to cytokine and chemokine induction, leukocyte recruitment, interstitial remodeling and fibrosis. Myocardial hibernation represents a part of the spectrum of ischemic cardiomyopathy, which in the absence of a completed myocardial infarction is a dynamic continuous process ultimately leading to irreversible injury and dysfunction. Understanding of the specific molecular signals involved in the pathogenesis of myocardial hibernation is crucial in order to design strategies preventing irreversible dysfunction. |
| | |
Authors:
|
N G Frangogiannis |
Related Documents
:
|
17433958 - Automated analysis of myocardial deformation at dobutamine stress echocardiography: an ... 11175138 - Long-term value of stress echocardiography in the triage of patients with atypical ches... 15757608 - Efficacy and safety of intermittent, long-term, concomitant dobutamine and levosimendan... 15936598 - Stress echocardiography: current methodology and clinical applications. 22434508 - Correlation of heart rate and cardiac dysfunction in duchenne muscular dystrophy. 8291508 - Sotalol: a new agent for the treatment of ventricular arrhythmias. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Minerva cardioangiologica Volume: 51 ISSN: 0026-4725 ISO Abbreviation: Minerva Cardioangiol Publication Date: 2003 Jun |
Date Detail:
|
Created Date: 2003-07-17 Completed Date: 2003-09-24 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0400725 Medline TA: Minerva Cardioangiol Country: Italy |
Other Details:
|
Languages: eng Pagination: 261-74 Citation Subset: IM |
Affiliation:
|
Section of Cardiovascular Sciences, Baylor College of Medicine, The Methodist Hospital and the DeBakey Heart Center, Houston, TX 77030, USA. ngf@bcm.tmc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Coronary Circulation / physiology Humans Myocardial Contraction / physiology Myocardial Stunning / diagnosis, pathology*, physiopathology, therapy* |
| Grant Support | |
ID/Acronym/Agency:
|
HL-42550/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Secondary unilateral cleft lip nasal deformity: functional and esthetic reconstruction.
Next Document: Life threatening ventricular arrhythmias with transient or correctable causes.