| Myocardial and hepatic T2* magnetic resonance evaluation in ex-thalassemic patients after bone-marrow transplantation. | |
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MedLine Citation:
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PMID: 17235481 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bone marrow transplantation (BMT) is the only complete cure for b-thalassemia. Iron depletion therapy is still required to remove excess iron, accumulated before BMT. Hepatic and myocardial iron load were evaluated using T2* magnetic resonance in 8 ex-thalassemic patients after BMT, aged 19.5 +/- 4.25 years, who were in iron depletion therapy. Average hepatic T2* was 18.8 +/- 11.0 msec (4.1-35.0 msec). In 4 out of 8 patients iron overload was detected, not exceeding however 4 mg/gr dry tissue. Average heart T2* was 31.0 +/- 4.6 msec (25.6-35.2 msec), not significantly different (P = 0.18) from our age-matched normal population (33.0 +/- 4.0). Normal left ventricular ejection fraction was found in 7 out of 8 patients (mean 64.5 +/- 7.0%) with the remaining having a marginal value of 54.1%. Ferritin level before BMT was 1748 +/- 451 mug/l and dropped to 536 +/- 260 microg/l at the end of iron depletion therapy after BMT. Current ferritin level was 271 +/- 253 microg/l and although it was significant lower compared to both ferritin before BMT (P < 0.001) and after iron depletion (P < 0.001), evidence of residual hepatic iron load was identified by T2*. Hepatic and myocardial T2* magnetic resonance can be used as a more reliable index than ferritin for evaluation of iron depletion therapy in ex-thalassemic patients after BMT. |
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Authors:
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Sophie Mavrogeni; Efstathios D Gotsis; Eleni Berdousi; Vasilios Ladis; Dimitrios Verganelakis; Panagiotis Toulas; Dennis V Cokkinos |
Publication Detail:
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Type: Journal Article Date: 2007-01-19 |
Journal Detail:
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Title: The international journal of cardiovascular imaging Volume: 23 ISSN: 1569-5794 ISO Abbreviation: Int J Cardiovasc Imaging Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-02 Completed Date: 2008-02-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100969716 Medline TA: Int J Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 739-45 Citation Subset: IM |
Affiliation:
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Onassis Cardiac Surgery Center, Athens, Greece. soma@aias.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Bone Marrow Transplantation* Child Female Humans Image Interpretation, Computer-Assisted Iron Overload / diagnosis* Liver / chemistry* Magnetic Resonance Imaging / methods* Male Myocardium / chemistry* Reproducibility of Results Statistics, Nonparametric beta-Thalassemia / pathology*, therapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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