Document Detail


Myocardial and hepatic T2* magnetic resonance evaluation in ex-thalassemic patients after bone-marrow transplantation.
MedLine Citation:
PMID:  17235481     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bone marrow transplantation (BMT) is the only complete cure for b-thalassemia. Iron depletion therapy is still required to remove excess iron, accumulated before BMT. Hepatic and myocardial iron load were evaluated using T2* magnetic resonance in 8 ex-thalassemic patients after BMT, aged 19.5 +/- 4.25 years, who were in iron depletion therapy. Average hepatic T2* was 18.8 +/- 11.0 msec (4.1-35.0 msec). In 4 out of 8 patients iron overload was detected, not exceeding however 4 mg/gr dry tissue. Average heart T2* was 31.0 +/- 4.6 msec (25.6-35.2 msec), not significantly different (P = 0.18) from our age-matched normal population (33.0 +/- 4.0). Normal left ventricular ejection fraction was found in 7 out of 8 patients (mean 64.5 +/- 7.0%) with the remaining having a marginal value of 54.1%. Ferritin level before BMT was 1748 +/- 451 mug/l and dropped to 536 +/- 260 microg/l at the end of iron depletion therapy after BMT. Current ferritin level was 271 +/- 253 microg/l and although it was significant lower compared to both ferritin before BMT (P < 0.001) and after iron depletion (P < 0.001), evidence of residual hepatic iron load was identified by T2*. Hepatic and myocardial T2* magnetic resonance can be used as a more reliable index than ferritin for evaluation of iron depletion therapy in ex-thalassemic patients after BMT.
Authors:
Sophie Mavrogeni; Efstathios D Gotsis; Eleni Berdousi; Vasilios Ladis; Dimitrios Verganelakis; Panagiotis Toulas; Dennis V Cokkinos
Publication Detail:
Type:  Journal Article     Date:  2007-01-19
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  23     ISSN:  1569-5794     ISO Abbreviation:  Int J Cardiovasc Imaging     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-02     Completed Date:  2008-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  739-45     Citation Subset:  IM    
Affiliation:
Onassis Cardiac Surgery Center, Athens, Greece. soma@aias.gr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bone Marrow Transplantation*
Child
Female
Humans
Image Interpretation, Computer-Assisted
Iron Overload / diagnosis*
Liver / chemistry*
Magnetic Resonance Imaging / methods*
Male
Myocardium / chemistry*
Reproducibility of Results
Statistics, Nonparametric
beta-Thalassemia / pathology*,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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